Insulin Resistance: Detection By Fasting Insulin In North Indian Obese Adults
Fasting Insulin and Insulin Resistance in Obese
Keywords:
Fasting Insulin, HOMA Index, Obesity, QUICKI IndexAbstract
Background&objectives:Several studies have shown that obesity is closely related to Insulin resistance(IR). Insulin resistance has been suggested as a primary cause for metabolic syndrome. Identifying such individuals would help to prevent progression of comorbidities associated with IR. Hence present study was planned to assess the importance of Fasting Insulin(FI) as a measure of IR and to analyze its correlation with other indirect methods for the assessment of IR . Methods: Study was conducted in fifty obese and overweight subjects.Body Mass Index of all subjects was calculated . Blood glucose, and FI were assayed after twelve hours of fasting. Homeostasis model assessment (HOMA) and Quantitative insulin sensitivity check indices (QUICKI) were calculated. Results: Present study showed that 90% of subjects had IR by HOMA and QUICKI.Correlation of FI with HOMA and QUICKI was statistically significant (P < 0.05). FI test had significant sensitivity and specificity when compared with HOMA and QUICKI indices. Validity of FI was further analyzed by Cohen’s kappa test and had good agreement (κ =0.67). Conclusion: FI was sensitive and also specific as HOMA and QUICKI in assessment of IR in obese. Thus, FI can be used as a simple test and feasable tool to detect IR in obese subjects. [AnshuKhatri NJIRM 2016; 7(5):1-4]
References
2. Sobngwi E, Mbanya JC, Unwin NC, Kengne AP, Fezeu L, Minkoulou EM, Aspray TJ, Alberti KG (2002). Physical activity and its relationship with obesity, hypertension and diabetes in urban and rural Cameroon Int. J. Obes. Relat.Metab.Disord. 2002; 26: 1009-1016.
3. Anastassios G. Pittas, Nandini A. Joseph, Andrews S. Greenberg . Adipocytokines and Insulin Resistance . The Journal of Clinical Endocrinology & Metabolism; 89(2) :447–452.
4. De Fronzo RA, Tobin JD, Andres R (1979). Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol.1979; 237: 214-223.
5. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Teacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b cell function from fasting plasma glucose and insulin concentration in man. Diabetologia.1985;28:412-419.
6. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method of assessing insulin sensitivity in humans. J. Clin. Endocrinol.Metab. 2000;85:2402- 2410.
7. McAuley KA, Williams SM, Mann JI, Walker RJ, Ledwis-Barned NJ, Temple LA, Duncan AS. Diagnosing insulin resistance in the general population. Diabetes Care.2001;24:460-464.
8. B. Antuna-Puente, M. Faraj, A.D. Karelis, D. Garrel , D. Prud’hommef, R. Rabasa-Lhoret , J.-P. Bastard. HOMA or QUICKI: Is it useful to test the reproducibility of formulas? Diabetes & Metabolism.2008; 34 : 294–296
9. McAuley KA, Williams SM, Mann JI, Walker RJ, Ledwis-Barned NJ, Temple LA,Duncan AS. Diagnosing insulin resistance in the general population.Diabetes Care 2001;24:460-464.
10. Ho-Won Lee, RanganathMuniyappa, Xu Yan, Lilly Q, Ellen H Linden, Hui Chen, Barbara C Hansen, MichaelJ.Quon. Comparison between Surrogate Indexes of Insulin Sensitivity/ Resistance and Hyperinsulinemic Euglycemic Glucose Clampsin Rhesus Monkeys. Endocrinology Scientific Research and Essays.2012; 7(25): 2218-2224
11. LukshmiM.Hettihewa,ShalikaPalangasinghe, SudheeraS Jayasinghe, Sudari W. Gunasekara, Thilak P Weerarathna. Comparison of insulin resistance by indirect methods- HOMA,QUICKI and McAuley-with fasting insulin in patients with type 2 diabetesinGalle ,SriLanka: ApilotStudy. OJHAS.2006;5(1):1-8
12. Ramesh Chand Chauhan, Neelima singh Chauhan, Manikandan,Anil Jacob Purty, Amit Kumar Mishra, Zile Singh. Obesity among adult population of a rural coastal area in south India.Int J Sci Rep. 2015;1(3):155-158
13. Khan BB, Flier JS. Obesity and insulin resistance. J. Clin.Invest. 2000; 106: 473-481.
14. Khalid M. Abu khadra, Ahmad Ajaberi. Anthropometric measures as predictors for the occurrence of insulin resistance among obese Jordanians.Scientific Research and Essays.2012; 7(25): 2218-2224
15. Robert Ross, Ian Janssen, Jody Dawson, Ann-Marie Kungl, Jennifer L. Kuk, Suzy L. Wong,et al. Exercise-Induced Reduction in Obesity and Insulin Resistance in Women: a Randomized Controlled Trial. Obesity Research.2004; 12( 5): 789-798.
16. M. ZafarIqbalHydrie, Abdul Basit, Asher Fawwad, Muhammad YakoobAhmedani, A. SamadShera and AkhtarHussain. Detecting Insulin Resistance in Pakistani Subjects by Fasting Blood Samples .The Open Diabetes Journal 2012: 5; 20-24.
17. KanwalMohinderDev Singh Panag, NavneetKaur, GitanjaliGoyal . Correlation of insulin resistance by various methods with fasting insulin in
obese.International Journal of Applied and Basic Medical Research.2014; 4:41-44.
