Effectiveness Of Blood Transfusion Therapy And Awareness Among Kinfolks Of Thalassemia Patients Visiting A Tertiary Care Hospital In North India
Effectiveness Of Blood Transfusion Therapy
DOI:
https://doi.org/10.70284/njirm.v7i3.1091Keywords:
Effectiveness Of Blood Transfusion TherapyAbstract
The thalassemia is the most prevalent
monogenic disease occurring at a high gene frequency
throughout the thalassemia belt extending from
Western Europe to Southeast Asia1. India, being
ethnically diverse, frequency varies between several
populations of different regions, averaging between 3-
4%2. β-thalassemias are characterized by decreased
synthesis of β globin chain of adult haemoglobin (HbA)
resulting in transfusion dependant anaemia
,ineffective erythropoiesis, bone deformities with
abnormal facies, hepatosplenomegaly and iron
overload3.
References
1. Simon TL, Synder EL, Solheim BG, Stowel CP,
Strauss RG, Petrides M. Rossi’s Principles of
Transfusion Medicine, 4th ed. Blackwell publishing
press; 2009.p.461.
2. Mohanty D, Colah RB, Gorakshakar AC, Patel RZ
,Master DC, Mahanta J et al. Prevalence of β-
thalassemia and other haemoglobinopathies in six
cities in India: a multicentric study. J Community
Genet. 2013; 4:33–42.
3. Hillyer CD, Silberstein LE, Ness PM, Anderson KC,
Roback JD. Blood Banking and TransfusionMedicine, Basic Principles and Practice, 2nd ed.
Churchill Livingstone Elsevier press; 2007.p 534.
4. Mittal K, Bedi RK, Sood T, Kaur P, Kaur G.
Transfusion support to thalassemic patients in a
resource poor setting: still a long way to go. Blood
Cells Mol Dis. 2014 Sep; 53(3):97-8.
5. Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P,
Vichinsky EP. Alloimmunization and erythrocyte
autoimmunization in transfusion-dependent
thalassemia patients of predominantly Asian
descent. Blood.2000; 96: 3369–73.
6. Chaudhari CN. Red cell alloantibodies in multiple
transfused thalassaemia patients. MJAFI. 2011;
67:34–37.
Strauss RG, Petrides M. Rossi’s Principles of
Transfusion Medicine, 4th ed. Blackwell publishing
press; 2009.p.461.
2. Mohanty D, Colah RB, Gorakshakar AC, Patel RZ
,Master DC, Mahanta J et al. Prevalence of β-
thalassemia and other haemoglobinopathies in six
cities in India: a multicentric study. J Community
Genet. 2013; 4:33–42.
3. Hillyer CD, Silberstein LE, Ness PM, Anderson KC,
Roback JD. Blood Banking and TransfusionMedicine, Basic Principles and Practice, 2nd ed.
Churchill Livingstone Elsevier press; 2007.p 534.
4. Mittal K, Bedi RK, Sood T, Kaur P, Kaur G.
Transfusion support to thalassemic patients in a
resource poor setting: still a long way to go. Blood
Cells Mol Dis. 2014 Sep; 53(3):97-8.
5. Singer ST, Wu V, Mignacca R, Kuypers FA, Morel P,
Vichinsky EP. Alloimmunization and erythrocyte
autoimmunization in transfusion-dependent
thalassemia patients of predominantly Asian
descent. Blood.2000; 96: 3369–73.
6. Chaudhari CN. Red cell alloantibodies in multiple
transfused thalassaemia patients. MJAFI. 2011;
67:34–37.
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Published
2018-01-21
How to Cite
Kaur, D., Doda, V., & Hemal, A. (2018). Effectiveness Of Blood Transfusion Therapy And Awareness Among Kinfolks Of Thalassemia Patients Visiting A Tertiary Care Hospital In North India: Effectiveness Of Blood Transfusion Therapy. National Journal of Integrated Research in Medicine, 7(3), 111–113. https://doi.org/10.70284/njirm.v7i3.1091
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