Lipoprotein Status And The Influence Of Age On Lipoprotein Status Among The Essential Hypertensives And Normotensives.
Lipoproteins & the influence of age on TSC in HTN & NTN.
DOI:
https://doi.org/10.70284/njirm.v6i3.898Keywords:
Hypertension, Hyperlipidaemias, Normotensives, AgeingAbstract
Background: Hypertension, hyperlipidaemias and ageing are considered major independent risk factors for cardiovascular morbidity and mortality. Although independent as risk factors, the three entities are closely related and often operate simultaneously to affect the cardiovascular system adversely, resulting eventually damage to various organs most notably heart, kidneys and brain. As the average blood pressure tends to rise progressively with increasing age, the prevalence of hypertension and atherosclerosis increases with ageing. Methodology: The present study comprised of 50 hypertensive and 50 normotensive subjects with Body Mass Index (BMI) less than 30. The controls selected were matched for age, sex, and dietary habits. The subjects with co-existing disorders of hypertension like diabetes, smokers, pregnancy and children are excluded. After overnight fasting of 12 to 14 hours, 5 ml of blood is collected from the subjects and selected biochemical parameters are measured and the data is statistically analysed. Results: The evaluation of lipid profile patterns in above subjects showed hypercholesterolaemia, hypertriglyceridaemia, increased LDL-C, total cholesterol / HDL-C ratio in hypertensives and decreased HDL-C levels in hypertensives when compared with normotensives. The Age influence on lipid profile patterns in above subjects showed significant increase in total cholesterol levels in normotensives with ageing than in hypertensives. There is significant increase in serum triacylglycerol levels in normotensives and hypertensives with ageing. There is also significant increase in total cholesterol / HDL-C ratio in normotensives with ageing than in hypertensives. Conclusion: This shows strong evidence for the increase in the risk for coronary artery disease with ageing in normotensives and once hypertension sets in there is no significant influence of age on associated dyslipidaemias. As age is a non-modifiable risk factor for coronary heart disease special care should be taken for the management of hypertension and abnormal lipid profiles in elderly subjects. The modifiable risk factors should be controlled by life style modification and pharmacological treatment of hypertension and dyslipidaemias. [Sanda S NJIRM 2015; 6(3):1-5]
References
2. Richard P. Ames. Hyperlipidemia in Hypertension: causes and prevention. American Heart Journal .1991 Oct; 122(4):1219-1224.
3. Ruixing, Yina, Jinzhen, Wua, Weixiong, Linb, Yuming, Chena, Dezhai, Yangb, Shangling, Pan. The environment and genetic evidence for the association of hyperlipidemia and hypertension. Journal of Hypertension.2009 Feb; 27(2):251-258.
4. Perreault S, Dorais M, Coupal L, Paradis G, Joffres M R, Grover S A. Impact of treating hyperlipidemia or hypertension to reduce the risk of death from coronary artery disease. Canadian Medical Association Journal.1999 May 18; 160(10):1449-1455.
5. Gred Assmann, Helmut Schulte. The Prospective Cardiovascular Munster (PROCAM) study: Prevalence of hyperlipidemia in persons with hypertensions and/or diabetes mellitus and relationship to coronary heart disease. American Heart Journal. 1988 Dec; 116(6):1713-1724.
6. Gred Assmann, Helmut Schulte. The Prospective Cardiovascular Munster (PROCAM) study: Prevalence and prognostic significance of hyperlipidemia in men with systemic hypertension. American Heart Journal. 1987 May 29; 59(14):G9-G17.
7. Zeiher A M, Drexler H, Saurbier B, Just H. Endothelium-mediated coronary blood flow modulation in humans. Effects of age atherosclerosis, hypercholesterolemia and hypertension. The Journal of Clinical Investigation.1993 Aug; 92(2):652-662.
8. Hunt S C, Wu L L, Hopkins P N, Stults B M, Kuida H, Ramirez M E, Lalouel J M, Williams R R. Apolopoproteins, Low density lipoprotein subfraction, and insulin association with familial combined hyperlipidemia. Study of Utah patients with familial dyslipidemic hypertension. Arteriosclerosis, Thrombosis,
and Vascular Biology: American Heart Association Journal.1989; 9:335-344.
9. Eric T.P Keulen, Christine Voors-Pette, Tjerk W.A de Bruin. Familial dyslipidemic hypertension syndrome: familial combined hyperlipidemia and the role of abdominal fat mass. American Journal of Hypertension.2001 April; 14(4):357-363.
10. Martin Rodriguez, Lilach O. Lerman, Joerg Hermann, Tatsuya sawamura, Claudio Napoli, Amir Lerman. Hypercholesterolemia and hypertension have synergistic deleterious effects on coronary endothelial function. Arteriosclerosis, Thrombosis, and Vascular Biology: American Heart Association Journal.2003 Mar 27; 23:885-891.
11. Romana T. Netea, Mihai G.Netea, Sebastian J.H. Bredie, Pierre N. M. Demacker, Nocolae Hancu, Theo Thein, Anton .F.H. Stalenhoef. Lipoprotein (a) concentrations in patients with familial combine hyperlipidemia and hypertension. The Netherland Journal of Medicine. 1999 July; 55(1):39-45.
12. Stefano Taddei, Augostino Viridis, Paola Mattei, Lorenzo Ghiadoni, Alessandra Gennari, Ciro Basile fasolo, Isabella Sudano, Antonio Salvetti. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation: American Heart Association Journal.1995; 91:1981-1987.
13. Kamran Tassaduqe, Tariq Aziz, Muhammad Ali, Shahnaz Kousar, Abdus Salam, Soban Umar. Studies on Lipid profile in relation to sex, Age in Non-Obese and Non Diabetic patients with Essential Hypertension among Human Population of Multan, Pakistan. Pakistan Journal of Biological Sciences .2003 ; 6(21);1814-1819.
