Community Acquired Bacterial Ocular Pathogens And Their Antibiotic Resistance In Western India.
Community Acquired Bacterial Ocular Pathogens And Their Antibiotic Resistance In Western India
DOI:
https://doi.org/10.70284/njirm.v6i2.889Keywords:
Ocular, bacterial infection, antibiotic resistanceAbstract
Background: Various type of ocular infections are responsible for increased prevalence of morbidity and blindness worldwide. Specific therapy of ocular infections often requires etiological diagnosis and antibiotic sensitivity profile for individual. Methodology: This study was conducted on 120 patients attending ophthalmology institute in tertiary care eye hospital. All patients were included consecutively after the initial clinical diagnosis of ocular infection. Brief clinical history and demographic data along with samples was collected and analyzed in proper manner in accordance with standard protocols. Results: Out of total 120 samples, 55 samples were positive for bacterial culture. Most common causative organism among gram negative isolates, was Pseudomonas (19/55) and in case of the gram positive isolates, was S. aureus (16/55). Maximum sensitivity was observed towards linezolid and vancomycin for gram positive isolates and for rest of others, imipenem and combinations antibiotics. Conclusion: The type and pattern of organisms that cause ocular infection changes over time. Antibiotics which have broad coverage, sensitivity and are effective enough to treat the common corneal pathogens should be used. [Patel P NJIRM 2015; 6(2):90-93]
References
2. Abbott RL, Kremer PA, Abrams MA. Bacterial Corneal Ulcers. Chapter 18 In: Duane’s Clinical Ophthalmology. Tasman N, Jaeger EA, Eds. (J.B Lippincott Company, Philadelphia) 1994;4:1-36.
3. Sharma S. Diagnosis of infectious diseases of the eye. [Abstract] Eye (London, England), 2012, vol. 26, issue 2, p 177, ISSN 14765454. ISBN 14765454.
4. Performance Standards for Antimicrobial Susceptibility Testing. Clinical and Laboratory Standards Institute 2011
5. K. Lily Therese, H.N. Madhavan. Microbiological procedures for diagnosis of ocular infections. Available from: www.ijmm.org/documents/ocular.pdf
6. Dhakhwa K, Sharma MK, Bajimaya S. Causative organisms in microbial keratitis. Nepal J Ophthalmol 2012; 4(7):119-127
7. Bashir G, Shah A, Thokar MA, Rashid S, Shakeel S. Bacterial and fungal profile of corneal ulcers—a prospective study. Indian J Pathol Microbiol. 2005 Apr;48(2):273-7
8. Schønheyder HC, Pedersen JK, Naeser K. Experience with a broth culture technique for diagnosis of bacterial keratitis. Acta Ophthalmol Scand. 1997 Oct;75(5):592-4.9. Dart JK. Predisposing factors in microbial keratitis, the significance of contact lens wear. Br J Ophthalmol. 1988 Dec;72(12):926-30.
10. AAS Dunlop, ED Wright. Suppurative corneal ulceration in Bangladesh A study of 142 cases examining the microbiological diagnosis, clinical and epidemiological features of bacterial and fungal keratitis. Australian and New Zealand Journal of Ophthalmology 1994; 22(2)
11. MJ Bharathi, R Ramakrishnan, S Vasu, R Meenakshi, C Shivkumar, R Palaniappan. Epidemiology of bacterial keratitis in a referral centre in south india. Indian Journal of Medical Microbiology, (2003) 21 (4):239-245
12. Bharathi MJ, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R. Aetiological diagnosis of microbial keratitis in south India. Indian J Med Microbiol 2002;20:19-24.
13. B L Sherwal, AK Verma. Epidemiology of Ocular Infection Due to Bacteria and Fungus – A Prospective Study. JK SCIENCE- July-September 2008 Vol. 10 No.3.
14. Liesegang TJ, Forster RK. Spectrum of microbial keratitis in south Florida. Am J Ophthalmol 1980;90:38-47.
15. Schaefer F, Bruttin O, Zografos L, Guex-Crosier Y. Bacterial keratitis: a prospective clinical and microbiological study. Br J Ophthalmol 2001;85:842-847.
16. Sharma S, Kunimoto DY, Garg P, Rao GN. Trends in antibiotic resistance of corneal pathogens. Part I. An analysis of commonly used ocular antibiotics. Indian J Ophthalmol 1999;47:95- 100
17. Savitri S, Derek K, Prashant G, Gullapalli R. Trends in antibiotic resistance of corneal pathogens: Part I. An analysis of commonly used ocular antibiotics. Indian J Ophthalmol 1999; 47:95-100.