Dress Syndrome: Time to Define Treatment Guidelines?
Dress Syndrome
DOI:
https://doi.org/10.70284/njirm.v5i5.812Keywords:
Dress Syndrome, Recovery, SteroidsAbstract
Background: DRESS (Drug rash with eosinophilia and systemic Symptoms) syndrome is a drug hypersensitivity syndrome which begins around 2- 6 weeks after exposure to a drug. If treated early, can recover completely and much of morbidity can be avoided. Case: A patient with history of taking carbamazepine for epilepsy, presented with typical features of maculopapular erythematous rash, exfoliative dermatitis and edema over upper and lower extremities, face, and trunk. He had eosinophilia, lymphadenopathy and elevated liver enzymes. His condition rapidly improved after withdrawing carbamazepine and starting steroids. Discussion: The rapid recovery with steroids in this case and in a few cases reported previously also suggests a need of RCT to assess steroids as an established modality for management of this severe but curable entity.[Muley A NJIRM 2014; 5(5):106-107]
References
2. Ghislain PD, Roujeau JC. Treatment of severe drug reactions: Stevens-Johnson syndrome, Toxic Epidermal Necrolysis and Hypersensitivity syndrome. Dermatology Online Journal2002;8:5.
3. Kim CW, Choi GS, Yun CH, Kim DI. Drug Hypersensitivity to Previously Tolerated Phenytoin by Carbamazepine- induced DRESS Syndrome. J Korean Med Sci2006;21:768-72.
4. Romero M N, Sendra T J, Raboso G E, Harto C A. Anticonvulsant hypersensitivity syndrome with fatal outcome. Eur J Dermatol2002;12:503-5.
5. Rauch A. E., Amyot K. M., Dunn H. G., Wilner G. Hypereosinophilic syndrome and myocardial infarction in a 15-year-old. PediatrPatholLab Med 1997;17:469-86.
