Serological Correlation of Clinically Suspected Cases of Leptospirosis in Valsad, South Gujarat

Serological Correlation Of Clinically Suspected Cases

Authors

  • Dr. Parimal Patel
  • Dr. Alka Nerurkar
  • Dr. Grishma Trivedi

DOI:

https://doi.org/10.70284/njirm.v5i4.761

Keywords:

IgM ELISA, Leptospirosis, Zoonosis

Abstract

Leptospirosis is a zoonotic infection with worldwide significance and a re-emerging public health problem in India. Since early 1980â€s the disease has been reported from various states during monsoon months. It is endemic in Gujarat, Andamans, Kerala, Tamil Nadu, Maharashtra, Karnataka and is also reported from Andhra Pradesh, West Bengal, Orissa, Puducherry, Delhi and Uttar Pradesh. Aim: Present study was undertaken to identify cases of Leptospirosis by Laboratory techniques. Materials and Methods: 136 samples have been considered for serological study in which 30 samples were taken as controls and 106 samples were of clinically suspected cases of leptospirosis. The study was conducted from July – October 2013 at our Tertiary care Hospital situated in South Gujarat. Serum samples of suspected cases of leptospirosis were collected and tested by Immunochromatography, IgM ELISA and MAT. Results: 63.20% of sera found to be positive for leptospirosis in which immunochromatography and IgM ELISA showed 66.98% and 66.98% positivity respectively. Conclusion: Study reveals that combination of IgM ELISA and MAT offer most reliable method for diagnosis of Leptospirosis. [Patel P NJIRM 2014; 5(4) :22-24]

References

1. Levett PN, Mandel GL, Mandell D: Mandell, Douglas & Bennett's Principles and Practice of Infectious Diseases. 7th edition. Philidelphia, 2010
2. Bharti AR, et al.: Leptospirosis: a zoonotic disease of global importance, Lancet Infect Dis 2003, 3(12):757-771
3. S. Shivakumar, Medicine Update 2008 Vol 18 799-809.
4. Trevejo RT, Rigau-Perez JG et al. Epidemic leptospirosis associated with pulnmonary haemorrhage- Nicaragua, 1995.J Infect Dis 1998:178:1457-63
5. Vinetz JM: Ten common questions about Leptospirosis. Infect Dis Clin Pract 200, 9(2):59-65.
6. Heath CWJ, Alexander AD et al (1965). Leptospirosis in Unitede States:Analysis of 483 cases in Man. N Eng J Med 273: 857-64.
7. Faine S (1982).Guidelines for control of leptospirosis. WHO offset publication No 67, Geneva.
8. Effler PV, Bogard AK et al. Evaluation of eight rapid screening tests for acute leptospirosis in Hawaii. J Clin Microbiol 40: 1464-69
9. Clerke AM, Leuva AC, Joshi C et al. Clinical profile of leptospirosis in South Gujrat. J Post Grad Med 2002. 48:117-118.
10. Patel BK, Gandhi SJ, Desai DC. Clinico epidemiological aspects of leptospirosis in South
Gujrat. Indian J Med Microbiol 2006 24(4). 322-326.
11. Levett PN: Leptospirosis, Clin Micro Review 2001, 14(2):296-326
12. Toyokawa T, Ohnishi M, Koizumi N: Diagnosis of acute leptospirosis. Expert Rev Anti Infect Ther 2011, 9(1):111-121
13. Bhardwaj RS,Bal AM, Joshi SA , Kagal AS, Arjunwadkar VP(2002) Common infection serovars in and around Pune, Maharastra, Indian J Med Res 115:194-96.
14. S.Shivkumar.Leptospirosis- Current scenario in india. Medicine Update 2008 vol.18 pp.799-804.
15. Tanvi Panwala,Summaiya Mulla, Parul Patel.Seroprevalence of leptospirosis in south Gujarat region by evaluating the two rapid commercial diagnostic kits aginst the MAT test for detection of antibodies to leptospira interrogans.National journal of Community Medicine 2011 vol.2(1) pp.64-70.
16. Smita B.Shekatkar, Belgode N.Harish, Godfred A.Menezes and Subhash C.Parija.J Infect Dev Ctries 2010;4(3):139-143.

Downloads

Published

2018-01-04

How to Cite

Patel, D. P., Nerurkar, D. A., & Trivedi, D. G. (2018). Serological Correlation of Clinically Suspected Cases of Leptospirosis in Valsad, South Gujarat: Serological Correlation Of Clinically Suspected Cases. National Journal of Integrated Research in Medicine, 5(4), 22–24. https://doi.org/10.70284/njirm.v5i4.761

Issue

Section

Original Articles