Alterations In Left Ventricular Diastolic Function In Hypothyroidism
Diastolic Dysfunction in Hypothyroidism
DOI:
https://doi.org/10.70284/njirm.v5i2.704Keywords:
Hypothyroidism, Left ventricular, pericardial effusion, diastolic dysfunctionAbstract
Background and Objectives: Hypothyroidism decreases the heart rate, cardiac output and
myocardial contractility. Altered intracellular Calcium handling results in left ventricular diastolic dysfunction in
hypothyroidism. Methods: 33 cases of primary hypothyroidism and 33 age (+/_ 5 years) and sex matched
healthy controls were studied. Thyroid profile and 2 D Echocardiography was done in all patients. Pulsed wave
Doppler examination to study the diastolic transmitral flow velocities was done to assess the left ventricular
diastolic function. Results: There was female preponderance (male to female ratio of 1:7.25), weight gain
(60.60% cases) being the most frequent presenting symptom. The mean BMI and mean systolic and diastolic
blood pressure were significantly increased in the cases (p<0.05). Hypothyroid patients had significant
bradycardia (p<0.05). 7(21.21%) patients had pericardial effusion. Statistically significant difference was found
in the IVST, PWT, IVRT and DT (p<0.05); the trans-mitral ‘A’ wave velocity was significantly increased in cases
(72.13 +/-13.27 Vs 65.48 =/-9.345; p=0.022). The ratio of E: A was significantly decreased in the hypothyroid
group (1.23 in cases and 1.38 in controls; p=0.011). Interpretation and Conclusion: Hypothyroidism results in
left ventricular structural changes in the form of concentric remodelling, pericardial effusion and left
ventricular diastolic dysfunction. [ Deoke S NJIRM 2014; 5(2) :66-70]
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