Prognostic Significance Of Serum Albumin Levels In Acute Ischemic Stroke
Prognostic Significance Of Serum Albumin
DOI:
https://doi.org/10.70284/njirm.v5i2.690Keywords:
albumin, Acute ischemic stroke, NIHSS score, Barthel indexAbstract
Objectives: Recent studies in acute ischemic stroke (AIS) have brought to light newer risk factors like serum levels of high sensitivity-C-Reactive Protein (hs-CRP), procalcitonin, homocysteine and albumin. Aim of our study is to objectively determine the short term prognostic value of serum albumin levels in AIS by correlating its levels with the clinical outcome. Methods: A cross-sectional study was carried out in Shri Sayajirao General Hospital, Vadodara over a period of 2 years where-in 108 cases of AIS were screened and 50 patients who met the inclusion criteria were studied. Patients presenting within 72 hours of onset and aged≥ 40 years were included in this study. Apart from routine investigations, serum albumin levels were done in all the patients. Results and Interpretation: Patients with a lower NIHSS score on admission had higher levels of serum albumin, and those with a higher National Institute of Health Stroke Scale (NIHSS) score had a lower level of albumin [P value <0.001]. Similarly, patients with a higher score on Barthel index after 1 week of admission had a higher serum albumin level, while those with lower score had lower albumin levels [P value <0.001]. Thus serum albumin level has a direct correlation with short term prognosis. [ Kasundra G NJIRM 2014; 5(2) :1-4]
References
2. Cho YM, Choi IS, Bian RX, Kim JH, Han JY, Lee SG. Serum albumin at admission for prediction of functional outcome in ischaemic stroke patients. Neurol Sci. 2008; 29: 445-449.
3. Idicula TT, Waje-Andreassen U, Brogger J, Naess H, Thomassen L. Serum albumin in ischemic stroke patients: the higher the better. The Bergen Stroke Study. Cerebrovasc Dis. 2009; 28: 13-17.
4. Tang J, Li YJ, Mu J, Li Q, Yang DY, Xie P. Albumin ameliorates tissue plasminogen activator-
mediated blood-brain barrier permeability and ischemic brain injury in rats. Neuronal Res. 2009; 31: 189-194.
5. Appel SA, Molshatzki N, Schwammenthal Y et al. Serum Calcium Levels and Long-Term Mortality in Patients with Acute Stroke. Cerebrovasc Dis. 2010; 16: 31: 93-99.
6. Sharma V, Giri S,agarwal MP. Correlation of Serum Albumin levels with Neurological Severity and Short term Outcome in Acute Ischemic troke. J Assoc Physicians India 2009; 74:115.
7. Dziedzic T, Pera J, Slowik A, Gryz-Kurek EA, Szczudlik A. Hypoalbuminemia in acute ischemic stroke patients: frequency and correlates. Eur J Clin Nutr. 2007; 61: 1318-1322.
8. Dziedzic T, Slowik A, Szczudlik A. Serum albumin level as a predictor of ischemic stroke outcome. Stroke. 2004; 35: 156–158.
9. Alvarez-PerezFJ, Castelo-Branco M, Alvarez-Sabin J. Albumin Level and Stroke. Potential Association Between Lower Albumin Level and Cardioembolic stroke. Int J Neuroscience. 2011; 121(1): 25-32.
10. Ginsberg MD, Palesch YY, Hill MD, Martin RH, Moy CS, Barson WG, et al. High-dose albumin treatment for acute ischaemic stroke (ALIAS) part 2: a randomised, double-blind, phase 3, placebo-controlled trial. The Lancet Neurology 2013; 12(11): 1049-1058.
