A Study Of N-Acetyl Cysteine On Clinical, Metabolic Parameter And Hormonal Profile In Women With Polycystic Ovarian Syndrome

Effect Of N-Acetyl Cysteine On Women With PCOS

Abstract

Background: Polycystic ovary disease (PCOD) is a common endocrine disorder, which is mainly characterized by infertility, anovulation, hyperinsulinemia, dyslipidaemia, biochemical imbalance. In our present study we have evaluated the effect of NAC in women suffering from PCOD in terms of their clinical, metabolic and hormonal parameters. Material And Methods: We conducted this prospective study for a period of 5 months on 60 women who are affected with PCOD (diagnosed by Rotterdam criteria) of age group 18–30 year, visiting OPD of obstetrics and gynaecology department of Acharya Vinobha Bhave Rural Hospital (AVBRH) Jawaharlal Nehru Medical College (J.N.M.C) located in Sawangi (Meghe), Wardha. Patients who had oligo/amenorrhoea, hirsutism (hyperandrogenism) and ultrasound finding (Polycystic ovaries) were included in this study. Clinical, metabolic parameter and hormonal profile were measured pre and post treatment with NAC. Result: Fifty-six patients who received tab N acetylcysteine 600 mg three times a day, shown improvement in BMI, waist circumference, WHR, fasting glucose, fasting insulin and total testosterone level after a period of 3 months but no significant reduction in weight. Conclusion: It has been concluded that longer treatment with N-acetyl cysteine may result in more desirable outcomes and more effective control of clinical symptoms of PCOS, hyperandrogenism, and carbohydrate parameters. So, NAC can be used as a insulin sensitizer drug for PCOS women. [T A Natl J Integr Res Med, 2021; 12(6): 9-13]