Autonomic Function Test In 72 Hours Post-Myocardial Infarction Patient

Autonomic Function Post Myocardial Ischemia

Abstract

Background: Survival after a Myocardial Infarction (MI) is determined by both left ventricular ejection fraction and ventricular arrhythmias which is tightly linked to autonomic dysfunction. Non-invasive autonomic function assessment in post infarction patients can be used for critical risk stratification among the same. Materials and Methods: This pilot case control study was conducted at department of Physiology and Cardiology of SRH University after approval from the institutional ethical committee. 30 post MI patients (72 hrs.) cases from department of cardiology & equal numbers of clinically healthy controls of similar age and gender were recruited following inclusion & exclusion criteria after written informed consent. Both the groups were interviewed for demographic, clinical, medical history, measured for anthropometry & investigatory parameters of Blood sugar &Serum creatinine. Later they were subjected to measurement of heart rate variability by polygraph using standard recording procedure. Data recorded was subjected descriptive and comparative analysis with p<0.05 as significant. Results: Significant sympatho-vagal imbalance (p=0.009)&decreased Parasympathetic system activity (HF) (p=0.02) was observed in Post MI cases as compared to controls. Conclusion: Reduced anti fibrillatory effect (Decreased parasympathetic activity) persisted past 72hrs of stable MIin adults (age < 65 yrs)and may be arisk factor for sudden cardiac death in such patients. [Mittal M Natl J Integr Res Med, 2020; 11(2):03-07]