Antimicrobial Sensitivity Pattern Of Salmonella Spp. Isolated From Blood Culture Of Clinical Suspected Case Of Enteric Fever

Antimicrobial Sensitivity Pattern Of Salmonella

Abstract

Background: Enteric fever is one of the most common systemic infections in developing countries. The increasing rate of resistance to the commonly used antibiotics & changing trends of antibiotic susceptibility has been of great concern in the proper treatment and prevention of this disease. This study aims to investigate the current antibiotic susceptibility pattern of Salmonella typhi, Salmonella paratyphi A & B. Method: This study was carried out at GCS Medical College, Hospital & Research Centre in Microbiology Department, over the period of six months from March 2019 to August 2019. Blood culture samples from a suspected case of enteric fever sent in microbiology laboratory. Patients of all the age groups were enrolled during the study. Antibiotic susceptibility test of isolated Salmonella spp. was performed by the modified Kirby Bauer Disc Diffusion method and results were interpreted according to Clinical and Laboratory Standards Institute (CLSI) guidelines. Result: Total 116 blood culture samples were found positive for Salmonella species. Out of these, 106(91.37%) were Salmonella Typhi, 8(6.89%) were Salmonella paratyphi A & 2(1.72%) were Salmonella paratyphi B. Isolates were mainly from pediatric age group. Salmonella spp. shown 100% sensitivity, towards Ampicillin, Amoxicillin, Ceftriaxone, Cefixime, Cefepime, Doxycycline & Cotrimoxazole. Sensitivity pattern of S.Typhi was (81%) to Ciprofloxacin, & (84.90%) to Azithromycin. Conclusion: Early diagnosis and appropriate antibiotic therapy reduced the public health burden of typhoid fever. Third generation cephalosporins were found most effective & can be used as an empiric choice or First-line agents for the management of Enteric fever. Nowadays Fluoroquinolone resistance in Salmonella species is rising. [Patel I Natl J Integr Res Med, 2019; 10(6):19-22]