Aceclofenac and Analgesic Nephropathy : A Transcendent Adverse Effect of Concern
Aceclofenac and Analgesic Nephropathy
DOI:
https://doi.org/10.70284/njirm.v10i1.2503Keywords:
Aceclofenac, Acute renal failure, Analgesic nephropathy, PharmacovigilanceAbstract
To eliminate the preventable deaths due to Acute Kidney Failure(ARF), especially due to chronic usage of over the counter non-steroidal anti-inflammatory drugs (NSAID) medications should be a pre-defined healthcare goal. Ever after the discovery of selective cyclooxygenase-2 (COX-2) inhibitors, nephrotoxicity still remains a concern. Here we are highlighting a case of Aceclofenac induced Acute on chronic renal disease exemplifying unregulated use of NSAIDs is an under recognized and potentially dangerous problem and that constant pharmacovigilance is the key to detect such events. This case was notified and uploaded to Vigiflow with I’d 2018-58102. Even after the availability of diversity of NSAIDs, a renal safe NSAID is yet to be discovered. [Pandya A Natl J Integr Res Med, 2019; 10(1):51-53]
References
2. Abdulla A, Adams N, Bone M, Elliot AM, Gaffin J, Jones D, Knaggs R, Martin D, Sampson L, Schofield P. Guidance on the management of pain in older people. Age Ageing. 2013;42:i1–i57
3. Ejaz P, Bhojani K, Joshi V. NSAIDS and kidney. J Assoc Physicians India. 2004;52:632–640.
4. Grosser T, Smyth EM, FitzGerald GA. Pharmacotherapy of Inflammation, Fever, Pain, and Gout. In: Brunton LB, Hilal-Dandan R, Knollmann BC(eds). Goodman & Gilman's The Pharmacological Basis of Therapeutics. 13th ed. New York, NY: McGraw-Hill; 2018: 689-691.
5. Crofford L. Rational use of analgesic and antiinflammatory drugs. N Engl J Med. 2001;345(25):1844–1846.
6. Broe M, Elseviers M. Over-the-counter analgesic use. J Am Soc Nephrol. 2009;20(10):2098–2103.
7. Pérez, S.; GarcÃa, L.A.; Raiford, D.S.; Duque, A.; Ris, J.; Non-steroidal anti-inflammatory drugs and the risk of hospitalization for acute renal failure. Arch. Intern. Med. 1996, 156, 2433-2439.
8. Perneger TV, Whelton PK, Klag MJ. Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs. N Engl J Med. 1994;331(25):1675–1679.
9. Feinstein A, Heinemann L, Curhan G, Delzell E, Deschepper PJ, Fox JM, Graf H, Luft FC, Michielson P, Mihatsch MJ, Suissa S, Woude FV, Willich S. Relationship between nonphenacetin combined analgesics and nephropathy: a review. Ad Hoc Committee of the International Study Group on Analgesics and Nephropathy. Kidney Int. 2000;58(6):2259–2264.
10. Dixit M, Doan T, Kirschner R, Dixit N. Significant Acute Kidney Injury Due to Non-steroidal Anti-inflammatory Drugs: Inpatient Setting. Pharmaceuticals (Basel). 2010;3(4):1279-1285.