Valproate induced Parkinsonism
Valproate induced Parkinsonism
DOI:
https://doi.org/10.70284/njirm.v9i6.2466Keywords:
Secondary Parkinsonism, Valproate, Adverse drug reaction, Causality Assessment, Preventable.Abstract
Drug induced Parkinsonism is common with neuroleptics drugs, antiemetic drugs but it is uncommon with antiepileptic drug such as Valproate (VAL). Neurological adverse effects of VAL are ataxia, tremor, sedation, lethargy, confusion, and more rarely encephalopathy and coma, have rarely been reported. Very rare cases of VAL induced Parkinsonism features associated with cerebral atrophy have been reported. The mechanism of these is currently unknown, but several hypotheses have been proposed. Possible mechanism can be, in vitro VAL can stimulate the activity of the GABA and Glutamate which can lead to Parkinsonism feature. Hence we reported a case of Parkinsonism developed after 6months of VAL treatment and also recovered after withdrawal of VAL. [ Patel S Natl J Integr Res Med, 2018; 9(6):72-74]
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