Valproate induced Parkinsonism

Valproate induced Parkinsonism

Authors

  • Shreya Patel Second Year Resident, N.H.L.Municipal Medical College, Ellis Bridge, Ahmedabad
  • Kamlesh Patel Associate Professor, N.H.L.Municipal Medical College, Ellis Bridge, Ahmedabad
  • Sapna Gupra Assistant Professor, N.H.L.Municipal Medical College, Ellis Bridge, Ahmedabad
  • Supriya Malhotra Professor and Head, Department of Pharmacology, N.H.L.Municipal Medical College, Ellis Bridge, Ahmedabad
  • Pankaj Patel Dean, N.H.L.Municipal Medical College, Ellis Bridge, Ahmedabad

DOI:

https://doi.org/10.70284/njirm.v9i6.2466

Keywords:

Secondary Parkinsonism, Valproate, Adverse drug reaction, Causality Assessment, Preventable.

Abstract

Drug induced Parkinsonism is common with neuroleptics drugs, antiemetic drugs but it is uncommon with antiepileptic drug such as Valproate (VAL). Neurological adverse effects of VAL are ataxia, tremor, sedation, lethargy, confusion, and more rarely encephalopathy and coma, have rarely been reported. Very rare cases of VAL induced Parkinsonism features associated with cerebral atrophy have been reported. The mechanism of these is currently unknown, but several hypotheses have been proposed. Possible mechanism can be, in vitro VAL can stimulate the activity of the GABA and Glutamate which can lead to Parkinsonism feature. Hence we reported a case of Parkinsonism developed after 6months of VAL treatment and also recovered after withdrawal of VAL. [ Patel S Natl J Integr Res Med, 2018; 9(6):72-74]

References

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Published

2018-12-31

How to Cite

Patel, S., Patel, K., Gupra, S., Malhotra, S., & Patel, P. (2018). Valproate induced Parkinsonism: Valproate induced Parkinsonism. National Journal of Integrated Research in Medicine, 9(6), 72–74. https://doi.org/10.70284/njirm.v9i6.2466

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Section

Case Report

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