A Comparative Study Of Pulmonary Functions In Different Age Groups
A Comparative Study Of Pulmonary Functions In Different Age Groups
DOI:
https://doi.org/10.70284/njirm.v4i3.2172Keywords:
Aging, FVC, FEV1, FEV1/FVC, PEFR, MVVAbstract
Background and objectives: The respiratory system changes with age and understanding these
changes helps detect and prevent respiratory dysfunctions in the elderly. Pulmonary function, as measured by
spirometry is an important predictor of morbidity and mortality of elderly persons. The aim of the present
study was to see the effects of aging on pulmonary functions. Methods : The study included 150 subjects of
different ages from 20 years and above. Subjects were divided in six groups depending on their age. (1) 20-29
yrs (2) 30-39 yrs (3) 40-49 yrs (4) 50-59 yrs (5) 60-69 yrs (6) 70 yrs and above. 25 subjects were included in
each group. FVC , FEV1, FEV1 /FVC%, PEFR, FEF25%-75%, MVV were measured. Results: Comparing 20-29 yrs with
70 yrs and above show mean FVC (4.33 vs 1.68 litre, p<0.001) ,FEV1(3.91 vs 1.19 litre p<0.001), FEV1
/FVC%(90.30 vs 70.0 p<0.001), PEFR(9.81 vs 3.31 lit/sec p<0.001), FEF25%-75%(6.65 vs 1.89 lit/sec p<0.001),
MVV(93.94 vs 55.96 lit/min p<0.001). Conclusion: Our study concluded that FVC, FEV1, FEV1/FVC, PEFR, FEF25-
75% and MVV decrease with age. It is probably a result of decreased strength of expiratory muscles, decreased
chest wall compliance and increased tendency of airways to close during forced expiratory effort causing air
trapping in the lungs.
References
teri a. Manolio, horace w. Bonekat,and paul l.
Enright , Am J Respir Crit Care Med 2001;Vol
163: p 61–68.
2. Gulshan Sharma,James Goodwin,Division of
Allergy, Pulmonary,Immunology, Critical Care,
and Sleep(APICS), Department of Internal
Medicine, University of Texas MedicalBranch,
Clinical Interventions in Aging 2006:1(3):253–
260.
3. Michael G. Levitzky Effects of Aging on the
Respiratory System Department of Physiology
Louisiana State University Medical Center New
Orleans, Louisiana 70112-l 393, The
physiologist, 1984, vol 27 no 2.
4. Muiesan, G., C. A. Sorbini, and V. Grassi.
Respiratory Function in the aged. Bull. Physio-
Pathol. Respir. 1971,7; 973-1009.
5. S.S verma, y .k Sharma and shikha arora et al a
multivariate study of some lung function tests
at different age group in healthy Indian male.
Indian j chest dis allied sci 2002;44:85-89.
6. Levent kart,md; inci gulmej ,fevziye certikaya
and mustafa cetin et al, pulmonary function of
healthy people in kayseri,turkiye ,Turkish
Respiratory Journal, August 2002, Vol.3, No.2.
A. K. De, M. B. Mandal and s. Kumar a crosssectional
study; indian j physiol pharmacol
2007; 51 (3) : 249–254.
7. S. Ostrowski, A. grzywa-celiñska, J.
Mieczkowska, M. RYCHLIK, P. Lachowskakotowska,
J. £opatyñski Pulmonary function
between 40 and 80 years of age journal of
physiology and pharmacology 2005, 56, supp 4,
127-133.
8. Kerstjens HA, Rijcken B, Schouten JP, et al.
Decline of FEV1 by age and smoking status:facts, figures,and fallacies. Thorax 1997;52:820–
7.
9. Raffaele Antonelli Incalzib Nicola Scichilonea
Franco Rengoc Spirometry Reference Values for
Women and Men Aged 65–85 Living in
Southern Europe:The Effect of Health utcomes:
Respiration 2003;70:484–489.
10. Hyun wook kim,md; seung teek yoo; sun hee
song et al . the effect of aging on the pulmonary
function of healthy adults Korean J Anesthesiol
1990 Dec 23(6):1021-1026.
11. Wahba w minfluence of aging on lung function
clinical. Significance of changes from age
twenty. Anesth. Analg. Cleveland 62:764-776,
1983.
12. N.B. Pride Ageing and changes in lung
mechanics.Thorax 1988;43:617-620
doi:10.1136/thx.43.8.617 .
13. Dikshit MB, Raje S, Agarwal MJ. Lung function
with spirometry: An Indian perspective-I Peak
expiratory flow rate. Indian J Physiol
Pharmacol 2005; 49: 8–18.
14. Enright P, Burchette R, Peters J, Lebowitz M,
McDonnell W, Abbey D. Peak flow lability:
association with asthma and spirometry in an
older cohort. Chest 1997; 112: 895-901.
15. Yoseph A Mengesha, Yalemtsehay Mekonnen
Spirometric lung function tests in normal nonsmoking
Ethiopian men and women Thorax
1985;40:465-468.
16. DuWayne Schmidt C, Dickman ML, Gardner RM,
Brough FK. Spirometric standards for healthy
elderly men and women: 532 subjects, ages 55
through 94 years.Am Rev Respir Dis 1973; 108:
933-939.
17. Kor AC, Ong KC, Earnest A, Wang YT.Prediction
of the maximal voluntary ventilation in healthy
adult Chinese subjects. Respirology. 2004
Mar;9(1):76-80.
18. Janssens, J. P., Pache J. C., Nicod, L. P. (1999).
Physiological changes in respiratory function
associated with ageing. European Respiratory
Journal. Jan;13(1):197-205.
19. Rossi, A., Ganassini, A., Tantucci, C. & Grassi, V.
(1996). Aging and the respiratory system. Aging
Clin Exp. Res, 8(3), 143-161.
20. Brown M, Hasser E. Complexity of age-related
change inskeletal muscle. J Gerontol A Biol Sci
Med Sci 1996; 51:117-123.
21. Tolep K, Kelsen S. Effect of aging on respiratory
skeletal muscles. Clin Chest Med 1993; 14: 363-
378.
