Importance of Adenosine Deaminase Estimation in Diagnosis of Tuberculous Pleural Effusion
ADA estimation in TB
DOI:
https://doi.org/10.70284/njirm.v3i5.2108Keywords:
Tuberculosis, ADA, Pleural effusionAbstract
Aim & Objective: To evaluate the usefulness of estimation of ADA (Adenosine deaminase) activity for etiological diagnosis of pleural effusion & to study the level of pleural fluid ADA in tuberculous & nontuberculous pleural effusion & establish cutoff limit of ADA activity. Materials & Methods: Present study was conducted in pathology department Pandit Dindayal Upadhyay Medical College Rajkot during year July 2005 to September 2007 for which we have taken 100 patients of all ages & either sex admitted in various medical wards, T.B. ward and O.P.D. Spectrophotometric method was used for ADA estimation. Results: The present study was carried out in 100 patients out of which 78 patients were of tuberculous pleural effusion & 22 cases were of Non-TB pleural effusion. There was minor difference in male & female Pleural Fluid (Both TB & Non TB) Mean ADA Level. Most of Tuberculous Effusion was in Range of 40-60 U/L ADA level (64 Pts) while Non Tuberculous effusion was between 16-20 U/L of ADA level (14 Pts). At level of 35 U/L of cut-off limit of ADA in pleural fluid sensitivity & specificity would be 94.7% & 72.7% respectively. Conclusion: The study concluded that estimation of ADA in Pleural Fluid is simple, rapid & less expensive laboratory investigation for diagnosis of tuberculous pleural effusion when diagnosis is uncertain by other investigation & it has valuable role as an adjuvant investigation to other diagnostic investigation of Tuberculosis.
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