Serum Iron And Ferritin As Diagnostic Marker of Breast Cancer
Serum Iron And Ferritin As Diagnostic Marker of Breast Cancer
DOI:
https://doi.org/10.70284/njirm.v9i1.1839Keywords:
Breast cancer, ferritin, iron, diagnostic markerAbstract
Background: It is the most frequently diagnosed cancer in women worldwide affecting. Risk of cancer increase with the age and it is higher in postmenopausal women. Iron deficiency anaemia is most prevalent in Indian women population. Association of serum iron profile and ferritin could be breakthrough for breast cancer detection and could become a future tumour marker. The aim of present study was to measure the serum ferritin, iron, total iron binding capacity and unbound iron binding capacity concentration in breast cancer patients to find out role of serum biochemical parameters (ferritin, iron, UIBC and TIBC) as biomarkers for diagnosis of breast cancer. Method: Total 100 cases were analysed during a period of 3 years they were histopathologically diagnosed breast cancer patients and age matched 100 healthy controls were taken . Levels of serum trace elements were estimated by colorimetric method SPSS version 17 were used for statistical confirmations. Result: Patients when compared to controls, Serum iron (124.87±39.12)and TIBC (318.5 ±62.97) were significantly lower and serum ferritin (188.93 ± 64.46) is significantly higher (p<0.001)in breast cancer patients and these parameters shows a significant positive correlation with tumour marker CA15-3. Conclusion: Based on findings our study concluded that breast tumours can cause increase serum level of iron ,ferritin and TIBC in female breast cancers patients and suggest that all these biochemical parameters can be used as a diagnostic marker for the follow-up of these breast cancer patients.
References
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21. Harshal P. Narkhede et al,‟Breast cancer and serum ferritin - Menopausal status perspective: Menopause - A fickle determinant,â€International Journal of Research in Medical Sciences Narkhede HP et al. Int J Res Med Sci. 2014 Feb;2(1):258-263 www.msjonline.org.
22. Kher A, Moghe G, Deshpande A. Significance of serum ferritin and lactate dehydrogenase in benign and malignant disease of breast. Indian J Pathol Microbiol.1997 Jul;40(3):321-6.
23. Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA. Serum parameters of iron metabolism in patients with breast cancer. Anticancer Res. 2003 Nov-Dec;23(6d):5107-9.
24. Moore AB. Dietary and stored iron as predictors of breast cancer risk: A nested case–control study in Shanghai. Int J Cancer. 2009 September;125(5):1110-7.
25. Goswami B, Tayal D, Mallika V. Ferritin: a multidimensional bio marker. Internet Journal of Laboratory Medicine. 2009;3(2).
26. Bae YJ. Dietary Intake and Serum Levels of Iron in Relation to Oxidative Stress in Breast Cancer Patients. J ClinBiochemNutr. 2009 November;45(3):355-60.
27. Wyllie S, Liehr JG. Enhancement of estrogeninduced renal tumorigenesis in hamsters by dietary iron. Carcinogenesis. 1998;19(7):1285-90.
28. Ebina Y, Okada S, Hamazaki S, Ogino F, Li FJ, Midorikawa O. Nephrotoxicity and renal cell carcinoma after use of iron- and aluminium nitrilotriacetate complexes in rats. J Natl Cancer Inst. 1986 Jan;76(1):107-13.
29. MairaMahmood, et al,‟ Comparison of Serum Ferritin with Carbohydrate Antigen 15-3 (CA 15-3)
in Breast Cancer patients in Pakistan,â€P J M H S OCT – DEC 2016Vol. 10, NO. 4:1384-89.
30. CujicD,Stefanoska I, Golubovi S. Serum ferritin in healthy women and breast cancer patients. J Med Biochem.2011; 30: 33–7.
31. Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA et al. Serum parameters of iron metabolism in patients with breast cancer. Anticancer Res. 2003; 23(6):5107-9.
32. Letiagin VP, Vysotskaia IV. Tumor markers CEA, CA 15-3, MCA, TPA, ferritin and PTH in the diagnosis and monitoring of primary breast cancer. VestnikRossiÄskoÄakademiimeditsinskikhnauk .1995; 4:4-10.
33. Kokocioska D, Widala E, Donocik J, Nolewajka E. The value of evaluating tumor markers: CA 15-3 and ferritin in blood serum of patients grouped as "high risk" for breast cancer. Przegladlekarski.1999; 56(10); 664-7.
2. over 17 lakes new cancer cases in india by 2020:ICMR ,Updated: May 18, 2016, 11:39 PM IST, PTI , http://www.dnaindia.com/ Breast cancer topped the list among females and among males mouth cancer, the study said.
3. Cecilia BoscoetalMetabolic serum biomarkers for the prediction of cancer.ecancer 2015, 9:555.
4. Beguin Y et al (2014) Epidemiological and nonclinical studies investigating effects of iron in carcinogenesis—a critical review Critical Rev Oncol/Hematol 89(1) 1–15 DOI: 10.1016/j.critrevonc.2013.10.008.
5. Weinberg ED (1996) The role of iron in cancer Eur J Cancer Prev 5(1) 19–36 PMID: 8664805.
6. Lamy PJ, Durigova A and Jacot W (2014) Iron homeostasis and anemia markers in early breast cancer ClinChimActa 434(0) 34–40 DOI: 10.1016/j.cca.2014.04.011 PMID: 24768787.
7. Sukiennicki et al. Hereditary Cancer in Clinical Practice 2015, 13(Suppl 2):A5http://www.hccpjournal.com/content/13/S2/A5.
8. Alkhateeb AA, Conner JR. Nuclear ferritin: A new role for ferritin in cell. Biology-BiochemBiophysActa, 2010 Aug; 1800 (8) : 793 -7.
9. A Jacobs, B. Jones, C. Ricketts, R. D. Bulbrook, and D. Y. Wang, "Serum ferritin concentration in early breast cancer," Br J Cancer, vol. 34, pp. 286-289, 1976.
10. M. H. Doner, A. Silverstone, K. Nishiya, A. De Sostoa, and M. De Sousa, "Ferritin synthesis by T lymphocytes," Science, vol. 209, pp. 1019-1021, 1980.
11. T. N. Tran, S. K. Eubanks, K. J. Schaffer, C. Y. Zhou, and M. C. Linder, "Secretion of ferritin by rat hepatoma cells and its regulation by inflammatory cytokines and iron," Blood, vol. 90, pp. 49794986, 1997
12. J. G. Liehr and J. S. Jones, "S. Role of iron in estrogen-induced cancer," Curr Med Chem., vol. 8, pp. 839-849, 2001.
13. R. G. Stevens, J. B. Cologne, K. Nakachi, E. J. Grant, and K. Neriishi, "Body iron stores and breast cancer risk in female atomic bomb survivors," Cancer Sci., vol. 102, pp. 2236-2240, 2011.
14. A J. Cross, M. J. Gunter, R. J. Wood, P. Pietinen, P. R. Taylor, and J. Virtamo, "Iron and colorectal cancer risk in the alpha-tocopherol, beta-carotene cancerprevention study," Int J Cancer, vol. 118, pp. 3147-3152, 2006.
15. J. Wish, "Assessing iron status: Beyond serum ferritin and transferrin saturation," Clin J Am SocNephrol., vol. Suppl 1, pp. S4-8, 2006.
16. Rufaida Mustafa Ahmed Mustafa, ‟Changesin SerumIron,TotalIronBindingCapacityandTransferrinSaturationPercentinSudaneseFemalesNewlyDiagnosedwithBreastCanceratKhartoumOncologyHospital: ACase-ControlStud,â€Sudan Journal of Medical Sciences Volume 12, Issue no. 3, DOI 10.18502/sjms.v12i3.915 Production and Hosting by Knowledge E.
17. V. Pavithra, T. G. Sathisha, K. Kasturi, D. Siva Mallika, S. Jeevan Amos, and S. Ragunatha, “Serum levels of metal ions in female patients with breast cancer,†Journal of Clinical andDiagnostic Research, vol. 9, no. 1, pp. BC25–BC27, 2015.
18. R.Dhankhar,A.C,K.Dahiya,V.S.Ghalaut,A.K.Dhull,andA.Khurana,“RoleofIron Metabolismin Breast Cancer Patients, â€Cancers Review,vol.1,no.2,pp.45–51,2014.
19. Basima Sadiq Ahmed et al, ‟Ferritin as a potent marker for breast cancer,â€International Journal of Technical Research and Applications e-ISSN: 2320-8163, www.ijtra.com Volume 3, Issue 2 (Mar-Apr 2015), PP. 184-187.
20. Sandhya Mishra et al, ‟studies of biochemical parameters in breast cancer with or without metastasis.â€Indian Journal of Clinical Biochemistry, 2004, 19 (1) 71-75.
21. Harshal P. Narkhede et al,‟Breast cancer and serum ferritin - Menopausal status perspective: Menopause - A fickle determinant,â€International Journal of Research in Medical Sciences Narkhede HP et al. Int J Res Med Sci. 2014 Feb;2(1):258-263 www.msjonline.org.
22. Kher A, Moghe G, Deshpande A. Significance of serum ferritin and lactate dehydrogenase in benign and malignant disease of breast. Indian J Pathol Microbiol.1997 Jul;40(3):321-6.
23. Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA. Serum parameters of iron metabolism in patients with breast cancer. Anticancer Res. 2003 Nov-Dec;23(6d):5107-9.
24. Moore AB. Dietary and stored iron as predictors of breast cancer risk: A nested case–control study in Shanghai. Int J Cancer. 2009 September;125(5):1110-7.
25. Goswami B, Tayal D, Mallika V. Ferritin: a multidimensional bio marker. Internet Journal of Laboratory Medicine. 2009;3(2).
26. Bae YJ. Dietary Intake and Serum Levels of Iron in Relation to Oxidative Stress in Breast Cancer Patients. J ClinBiochemNutr. 2009 November;45(3):355-60.
27. Wyllie S, Liehr JG. Enhancement of estrogeninduced renal tumorigenesis in hamsters by dietary iron. Carcinogenesis. 1998;19(7):1285-90.
28. Ebina Y, Okada S, Hamazaki S, Ogino F, Li FJ, Midorikawa O. Nephrotoxicity and renal cell carcinoma after use of iron- and aluminium nitrilotriacetate complexes in rats. J Natl Cancer Inst. 1986 Jan;76(1):107-13.
29. MairaMahmood, et al,‟ Comparison of Serum Ferritin with Carbohydrate Antigen 15-3 (CA 15-3)
in Breast Cancer patients in Pakistan,â€P J M H S OCT – DEC 2016Vol. 10, NO. 4:1384-89.
30. CujicD,Stefanoska I, Golubovi S. Serum ferritin in healthy women and breast cancer patients. J Med Biochem.2011; 30: 33–7.
31. Ulbrich EJ, Lebrecht A, Schneider I, Ludwig E, Koelbl H, Hefler LA et al. Serum parameters of iron metabolism in patients with breast cancer. Anticancer Res. 2003; 23(6):5107-9.
32. Letiagin VP, Vysotskaia IV. Tumor markers CEA, CA 15-3, MCA, TPA, ferritin and PTH in the diagnosis and monitoring of primary breast cancer. VestnikRossiÄskoÄakademiimeditsinskikhnauk .1995; 4:4-10.
33. Kokocioska D, Widala E, Donocik J, Nolewajka E. The value of evaluating tumor markers: CA 15-3 and ferritin in blood serum of patients grouped as "high risk" for breast cancer. Przegladlekarski.1999; 56(10); 664-7.
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Published
2018-02-28
How to Cite
Vamne, A., Sarkar, P., & sodavadiya, K. (2018). Serum Iron And Ferritin As Diagnostic Marker of Breast Cancer: Serum Iron And Ferritin As Diagnostic Marker of Breast Cancer. National Journal of Integrated Research in Medicine, 9(1), 1–6. https://doi.org/10.70284/njirm.v9i1.1839
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