A Prospective, Single Centric Study of Hematological Profile in HIV Infected Patients with Correlation to CD4 Count
A Prospective, Single Centric Study of Hematological Profile in HIV Infected Patients with Correlation to CD4 Count
DOI:
https://doi.org/10.70284/njirm.v8i2.1231Keywords:
CD4, HIV, Haematological changesAbstract
Background & objectives: A variety of haematological manifestations is seen at every stage of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) and often pose a great challenge in the comprehensive management. These manifestations also reflect the underlying immune status if interpreted cautiously, especially if the patient is in regular follow-up. They may cause symptoms that are life-threatening and impair the quality of life of these patients. Methods: Blood samples collected in the ART centre send to the central pathology laboratory, Sir Takhtasinhji General Hospital, Bhavnagar. Haematological parameters were analysed by automated haematology analyser and peripheral smear examination. CD4 count was done by automated analyser. Descriptive statistics were applied. Association between two attributes was calculated by chi-square test, Kruskal-Wallis test, one way ANOVA test, unpaired t test and Mann Whitney test and P value less than 0.05 was considered statistically significant. Results: Comparison between CD4 count and haematological changes shows that p value is significant (P<0.05) in haemoglobin, total leucocyte count, differential leucocyte count except absolute eosinophil count, platelet, PCV and blood indices except in MCHC. Male: Female ratio is 2:1. 86 % was sexually transmitted, 1.6% by blood transfusion, 7.4% by vertical transmission, 5% by unknown reason. Maximum 44.4% patients have CD4 count between 200-499 cells/cumm. Anaemia is present in 47.4% patients. Leucopenia is present in 11.2% patients. Lymphopenia is present in 12.8% patients and eosinophilia is present in 6% patients. Thrombocytopenia is present in 8.6% patients. Interpretation & conclusion: Haematological changes are occurs along with changes in CD4 count and disease progression. Along with changes in CD4 count changes in haemoglobin, leucocytes and platelet occurs along with other haematological changes. Haematological parameters correlate with level of CD4 count. [Heema C NJIRM 2017; 8(2):169-176]
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