Comparative Evaluation Of C-Reactive Protein Levels And Leucocyte Counts In Patients With Sickle Cell Anemia, Chronic Generalized Periodontitis And Sickle Cell Anemia With Chronic Periodontitis: A Clinico-Biochemical Study
CRP in Sickle Cell Anemia & Chronic Periodontitis
DOI:
https://doi.org/10.70284/njirm.v7i4.1098Keywords:
Chronic generalized periodontitis (CGP), C‑reactive protein (CRP), leucocyte counts, Sickle cell anemia (SCA)Abstract
Aim: The aim of this study is to compare the CRP levels and leucocyte counts in patients with Sickle cell anemia, Sickle cell anemia with chronic periodontitis, and chronic periodontitis. Material andMethods: A total of 90 subjects with an age range of 30-50 years having sickle cell anemia and chronic periodontitis with probing depth ≥5mm and clinical attachment level ≥ 5mm were included and three groups: Group I- Sickle cell anemia; Group II- Sickle Cell anemia with chronic periodontitis and Group III: Chronic severe periodontitis. Blood samples for CRP and leucocytes counts estimation were collected. All participants were subjected to quantitative CRP analysis. Results: Mean CRP levels and leucocyte counts were significantly greater in group II as compared to group I and group III. Conclusion: The present study indicates a positive correlation in CRP levels and leucocyte counts in patients with Sickle cell anemia, chronic periodontitis and both. [Sachin M NJIRM 2016; 7(4):22-27]
References
1. de Maat MP, Kluft C. Determinants of C‑reactive protein concentration in blood. Ital Heart J 2001; 2:189‑95.
2. Damanhouri G, Jarullah J, Marouf S, Hindawi S, Mushtaq G and Kamal M. Clinical biomarkers in sickle cell disease. Saudi Journal of Biological Sciences. 2015; 22(1): 24-31.
3. Ablij H, Meinders A. C‑reactive protein: history and revival. Eur J Intern Med. 2002; 13:412.
4. Kushner I. C‑reactive protein in rheumatology. Arthritis Rheum 1991; 34:1065‑8.
5. Ridker PM. Clinical application of C‑reactive protein for cardiovascular disease detection and prevention. Circulation 2003; 107:363‑9.
6. Ridker PM. High‑sensitivity C‑reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001; 103:1813‑8.
7. Bargoma, E.M., Mitsuyoshi, J.K., Larkin, S.K., Styles, L.A., Kuypers, F.A., Test, S.T. Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vaso-occlusive crisis or acute chest syndrome. Blood 2005; 105: 3384–3385.
8. Charache, S. Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults. Semin. Hematol. 1997; 34: 15–21.
9. Janket SJ, Baird AE, Chuang SK, Jones JA. Meta‑analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95:559‑69.
10. Meurman JH, Sanz M, Janket SJ. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15:403‑13.
11. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C‑reactive protein level. J Periodontol 2001; 72:1221‑7.
12. Pitiphat W, Joshipura KJ, Rich‑Edwards JW, Williams PL, Douglass CW, Gillman MW.
Periodontitis and plasma C‑reactive protein during pregnancy. J Periodontol 2006; 77:821‑5.
13. Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Iida M, et al. Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: The Hisayama study. J Periodontal Res. 2005; 40:346‑53.
14. Okpala I. The intriguing contribution of white blood cells to sickle cell disease - a red cell disorder. Blood Rev. 2004; 18(1): 65-73.
15. CE Okocha, PO Manafa, and JC Aneke. C - reactive protein and Disease Outcome in Nigerian Sickle Cell Disease Patients. Ann Med Health Sci Res.2014: 4(5): 701-705.
16. Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, et al. Oxidative stress and inflammation in iron‑overloaded patients with beta‑thalassaemia or sickle cell disease. Br J Haematol. 2006; 135:254‑63.
17. Zacho J, Tybjaerg‑Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG. Genetically elevated C‑reactive protein and ischemic vascular disease. N Engl J Med. 2008; 359:1897‑908.
18. Olaniyi J and Arinola G. Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria. Turk J Med Sci. 2009; 39 (6): 953-957.
19. Damanhouri G, Jarullah J, Marouf S, Hindawi S, Mushtaq G and Kamal M. Clinical biomarkers in sickle cell disease. Saudi Journal of Biological Sciences. 2015; 22(1): 24-31.
20. Rose LF, Genco RJ, Cohen DW,Mealey BL. Periodontal Medicine. Hamilton,Ontario: B.C.Decker Inc. 2000: 73-78.
21. Wu T, Trevisan M, Genco RJ, Falkner KL,Dorn JP, Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: Serum total and high density lipoprotein cholesterol, C-reactive protein,and plasma fibrinogen. Am J Epidemiol 2000; 151: 273-282.
22. Rider PM, Cushman M, Stampfer MJ, Tracy RP, Henekens CH. Inflammmation, aspirin and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-979.
23. Rider PM, Cushman M, Stampfer MJ, Tracy RP, Henekens CH. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation 1998; 97: 425-428.
24. Rider PM, Glynn RJ, Henekens CH. C-reactive protein ads to the predictive value of total and HDLcholesterol in determing risk of first myocardial infarction. Circulation. 1998; 97: 2007-2011.
25. Rider PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and risk for future cardiovascular events among apparently healthy women. Circulation 1998; 98: 731-733.
26. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Mointoring trends and Determinants in Cardiovascular Disease)Augsburg Cohort study, 1984-1992.Circulation 1999; 99: 237-242.
27. Rider PM, Hennekens CH, Buring JE,Rofai N. C-reactive protein and other markers of inflammationin the prediction of cardiovascular disease in women. N Engl J Med 2000; 342: 836-843.
2. Damanhouri G, Jarullah J, Marouf S, Hindawi S, Mushtaq G and Kamal M. Clinical biomarkers in sickle cell disease. Saudi Journal of Biological Sciences. 2015; 22(1): 24-31.
3. Ablij H, Meinders A. C‑reactive protein: history and revival. Eur J Intern Med. 2002; 13:412.
4. Kushner I. C‑reactive protein in rheumatology. Arthritis Rheum 1991; 34:1065‑8.
5. Ridker PM. Clinical application of C‑reactive protein for cardiovascular disease detection and prevention. Circulation 2003; 107:363‑9.
6. Ridker PM. High‑sensitivity C‑reactive protein: Potential adjunct for global risk assessment in the primary prevention of cardiovascular disease. Circulation 2001; 103:1813‑8.
7. Bargoma, E.M., Mitsuyoshi, J.K., Larkin, S.K., Styles, L.A., Kuypers, F.A., Test, S.T. Serum C-reactive protein parallels secretory phospholipase A2 in sickle cell disease patients with vaso-occlusive crisis or acute chest syndrome. Blood 2005; 105: 3384–3385.
8. Charache, S. Mechanism of action of hydroxyurea in the management of sickle cell anemia in adults. Semin. Hematol. 1997; 34: 15–21.
9. Janket SJ, Baird AE, Chuang SK, Jones JA. Meta‑analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95:559‑69.
10. Meurman JH, Sanz M, Janket SJ. Oral health, atherosclerosis, and cardiovascular disease. Crit Rev Oral Biol Med 2004; 15:403‑13.
11. Noack B, Genco RJ, Trevisan M, Grossi S, Zambon JJ, De Nardin E. Periodontal infections contribute to elevated systemic C‑reactive protein level. J Periodontol 2001; 72:1221‑7.
12. Pitiphat W, Joshipura KJ, Rich‑Edwards JW, Williams PL, Douglass CW, Gillman MW.
Periodontitis and plasma C‑reactive protein during pregnancy. J Periodontol 2006; 77:821‑5.
13. Saito T, Shimazaki Y, Kiyohara Y, Kato I, Kubo M, Iida M, et al. Relationship between obesity, glucose tolerance, and periodontal disease in Japanese women: The Hisayama study. J Periodontal Res. 2005; 40:346‑53.
14. Okpala I. The intriguing contribution of white blood cells to sickle cell disease - a red cell disorder. Blood Rev. 2004; 18(1): 65-73.
15. CE Okocha, PO Manafa, and JC Aneke. C - reactive protein and Disease Outcome in Nigerian Sickle Cell Disease Patients. Ann Med Health Sci Res.2014: 4(5): 701-705.
16. Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, et al. Oxidative stress and inflammation in iron‑overloaded patients with beta‑thalassaemia or sickle cell disease. Br J Haematol. 2006; 135:254‑63.
17. Zacho J, Tybjaerg‑Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG. Genetically elevated C‑reactive protein and ischemic vascular disease. N Engl J Med. 2008; 359:1897‑908.
18. Olaniyi J and Arinola G. Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria. Turk J Med Sci. 2009; 39 (6): 953-957.
19. Damanhouri G, Jarullah J, Marouf S, Hindawi S, Mushtaq G and Kamal M. Clinical biomarkers in sickle cell disease. Saudi Journal of Biological Sciences. 2015; 22(1): 24-31.
20. Rose LF, Genco RJ, Cohen DW,Mealey BL. Periodontal Medicine. Hamilton,Ontario: B.C.Decker Inc. 2000: 73-78.
21. Wu T, Trevisan M, Genco RJ, Falkner KL,Dorn JP, Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: Serum total and high density lipoprotein cholesterol, C-reactive protein,and plasma fibrinogen. Am J Epidemiol 2000; 151: 273-282.
22. Rider PM, Cushman M, Stampfer MJ, Tracy RP, Henekens CH. Inflammmation, aspirin and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997; 336: 973-979.
23. Rider PM, Cushman M, Stampfer MJ, Tracy RP, Henekens CH. Plasma concentration of C-reactive protein and risk of developing peripheral vascular disease. Circulation 1998; 97: 425-428.
24. Rider PM, Glynn RJ, Henekens CH. C-reactive protein ads to the predictive value of total and HDLcholesterol in determing risk of first myocardial infarction. Circulation. 1998; 97: 2007-2011.
25. Rider PM, Buring JE, Shih J, Matias M, Hennekens CH. Prospective study of C-reactive protein and risk for future cardiovascular events among apparently healthy women. Circulation 1998; 98: 731-733.
26. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: Results from the MONICA (Mointoring trends and Determinants in Cardiovascular Disease)Augsburg Cohort study, 1984-1992.Circulation 1999; 99: 237-242.
27. Rider PM, Hennekens CH, Buring JE,Rofai N. C-reactive protein and other markers of inflammationin the prediction of cardiovascular disease in women. N Engl J Med 2000; 342: 836-843.
Downloads
Published
2018-01-22
How to Cite
J, S. M. J., S, S., S, A., S, P., & B, P. (2018). Comparative Evaluation Of C-Reactive Protein Levels And Leucocyte Counts In Patients With Sickle Cell Anemia, Chronic Generalized Periodontitis And Sickle Cell Anemia With Chronic Periodontitis: A Clinico-Biochemical Study: CRP in Sickle Cell Anemia & Chronic Periodontitis. National Journal of Integrated Research in Medicine, 7(4), 22–27. https://doi.org/10.70284/njirm.v7i4.1098
Issue
Section
Original Articles
