Pattern Of Reticulocyte Count And Hemoglobin Concentration In Pregnant And Non- Pregnant Women In Rural Haryana.

Pattern Of Reticulocyte Count And Haemoglobin Concentration In Pregnant And Non-Pregnant Women In Rural Haryana

Authors

  • Deepsheikha Dhand
  • Nasib Chand
  • Sanjay Bedi
  • Tanupriya Bindal
  • Minu Bedi

Keywords:

Haemoglobin, Anemia, Reticulocyte count, Trimester, Hematological, Bone marrow

Abstract

Background & Objective: Anemia is a common nutritional health problem in women’s child bearing age.
Pregnant women are at higher risk particularly during 3rd trimester of pregnancy. By definition, it is decrease in
number of RBCs below 4.5 million or Hb level below 11.0 gm % and hematocrit < 0.33 in pregnant women. Anemia
contributes significantly to maternal mortality and morbidity and also carries a risk factor for infant iron deficiency
anemia. Main causes of maternal anemia are blood loss, increased menstrual bleeding and nutritional iron & folate
deficiency. Anemia can be estimated by Hb estimation and Reticulocyte count (RC), which is a quantitative measure
of Bone marrow production of new RBCs, with a range of 0.5-2.5%(adults) and 2.6% in infants. Reticulocyte Index (RI)
is a calculation of ratio b/w level of anemia in response to which, RC has risen. Objective is to study pattern of
reticulocyte count in pregnant and non-pregnant women, 2) To compare Hb level in pregnant women in 3 trimesters
and non-pregnant women.3) To analyze pattern of reticulocyte count and compare levels of Hb concentration in
pregnant women in 3 trimesters and non- pregnant women. Methodology: A total of 100 women with age range of
18-40 yrs were examined (50 pregnant and 50 healthy non pregnant women) presenting to Obstetrical O.P.D. Blood
samples from subjects were collected, tested and hematologically analyzed. Both Inclusion and Exclusion criteria
strictly followed. Results & Conclusion: Hb level in pregnant women was significantly low as compared to non
pregnant women, whereas Reticulocyte count was higher in pregnant women than non pregnant women. Variation
of Hb concentration was seen as, high in 3rd Trimester. R C was raised in 2nd Trimester and reached peak in 3rd
trimester, while it remained normal or decreased in 1st trimester. Non-pregnant women showed normal range of R C.
So values of all red cell parameters in pregnant women was significantly low, as compared to age matched controls
except Reticulocyte count, which was raised during pregnancy. [Bedi S NJIRM 2016; 7(3): 40 - 44]

References

1. Kothari R, Bokariya P, Kothari V. A study of
erythron status in pregnant and non-pregnant age
matched females of Jodhpur Region. J Pharmacy
2013;3(1):35-9.
2. Lee GR, Herbert V. Nutritional factor in the
production and function of erythrocytes. In Lukens
J, Paraskevas P, Greer JP, Rodgers GM editors.
Wintrobe’s clinical hematology. Baltimore,
Maryland USA: William $ Wilkins;1998. P 228-66.
3. Ezzati M, Lopez AD, Dogers A, Vander HS, Murray
CJ. Selected major risk factors and global and
regional burden of disease. Lancet 2002; 360:1347-
60.
4. Agarwal KN.The effects of maternal iron deficiency
on placenta and fetus. In Jelliffe DB, Jelliffe FEP,
editors. Advances in international maternal child
health. Oxford calarendon Press; 1984;4. P 26-35.
5. Agarwal RMD, Tripathi AM, Agarwal KN. Cord
blood hemoglobin, iron and serum ferrite status in
maternal anaemia. Acta Paediatr Scand 1983;
74:545-8l .
6. Agarwal KN. Iron and brain; neurotransmitter
receptors and magnetic response spectroscopy. Br
J Nutr 2001;85 (Suppl 2 ) :S147-50.
7. Kapur D, Agarwal KN, Agarwal DK .Nutritional
anemia and its control. Indian J Pediatr 2002;
69:607-16.
8. Little MP, Brocard P, Elliot P, Steer PJ. Hemoglobin
concentration pregnancy and perinatal mortality:
A London – based cohort Study. Am J Obstet G
ynecol 2005; 193:220- 6.
9. Xiong X, Buekens P, Alexender S, Demianczuk N,
Wollast E. Anemia during pregnancy and birth
outcome: a meta-analysis. Am J Perinat 2000;17(3)
10. Steer P, Alam MA, Wadsworth J, Welch A. Relation
between maternal hemoglobin concentration and
birth weight in different ethnic groups. BMJ 1995;
310:489-91.
11. Bodnar LM, Scanlon KS, Freedman DS, Siega-Riz
AM, Cogswell ME. High prevalence of postpartum
anemia among low-income women in the United
States. Am J Obstet Gynecol 2001; 185:438-43.
12. Van Vyck DB, Martens MG, Sied MH. Intravenous
ferric carboxymaltose compared with oral iron in
the treatment of postpartum anemia. A
randomized controlled trial. Obstet Gynecol
2007;110: 267-78.
13. Corwin EJ, Arbour M. Postpartum fatigue and
evidence-based interventions. Abstract MCN;32(4)
14. Weiss G. Modification of iron regulation by the
inflammatory response. Best Practice Research
Clin Hematol 2005;18: 183-201.
15. Weyermann M, Rothenbacher D, Gayer L, Bode G.
Role of helicobactor pylori infection in iron
deficiency during pregnancy. Am J Obstet Gynecol
2005; 192: 548-53.
16. Troy NW. Is the significance of postpartum fatigue
being over looked in the lives of Women? MCN
The Am J Maternal /Child Nursing 2003;28: 252-
257.
17. Breymann C, Zimmermann R , Huch R, Huch A. Use
of recombinant human erythropoietin in
combination with parenteral iron in the treatmentof postpartum anemia. European J Clin Invest
1992;26: 123-130.
18. Beard J,Hendricks M, Perez E, Murray-Kolb L,Berg
A, Vernon-Feagans l, Irlam J, Isaacs W,Sive A,
Tomlinson M. Maternal iron deficiency anaemia
affects postpartum emotion and cognition. Am
Society for Nutritional Science 2005;267-271.
19. Hoffbrand A.V,| Moss P.A.H. Erythropoiesis and
general aspects of anaemia. In:Essential
Haematology. Hoboken, New Jersey USA: Wiley –
Blackwell; 2011p.17-32.
20. Pritchard JA , Adams RH. Erythrocyte production
and destruction during pregnancy. Amer J Obestet
Gynec 1960;79: 750-57

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Published

2018-01-21

How to Cite

Dhand, D., Chand, N., Bedi, S., Bindal, T., & Bedi, M. (2018). Pattern Of Reticulocyte Count And Hemoglobin Concentration In Pregnant And Non- Pregnant Women In Rural Haryana.: Pattern Of Reticulocyte Count And Haemoglobin Concentration In Pregnant And Non-Pregnant Women In Rural Haryana. National Journal of Integrated Research in Medicine, 7(3), 40–44. Retrieved from https://nicpd.ac.in/ojs-/index.php/njirm/article/view/1074

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