To Establish The Involvement Of Central Dopaminergic And Serotonergic Mechanism Of Ginger-Juice On Amphetamine And Lithium Treated Rat

To Establish The Involvement Of Ginger-Juice On Amphetamine And Lithium Treated Rat

Authors

  • S.S. Prasad
  • Chaitali Shah
  • Anupama Desai
  • S.K. Vajpeyee
  • V.H. Bhavsar

DOI:

https://doi.org/10.70284/njirm.v7i1.1046

Keywords:

Ginger-juice, Amphetamine,Lithium, Locomotor, static activity, analgesic

Abstract

Background & Objective: To establish the involvement of central dopaminergic and serotonergic mechanismof ginger-juice (ZINGIBER OFFICINALE ROSCOE) CNS parameters in rat. Methodology: (A) Albino rats (n=6-12) were administered G.J at two doses (2ml & 4 ml/rat, p.o) as single administration and chronic treatment over period of 30 days. Following this assessment was done. Effect of treatment with G.J acutely and chronically (30days) administered, was assessed. Parameters used during assessment were total acidity, gastric volume & pH and ulcer index ‘UI’(acute and chronic). Results & Conclusion: Ginger administered itself did not affect loco motor activity as well as amphetamine-induced enhancement of loco motor activity.Lithium induced head twitches were enhanced after chronic administration indicating enhanced serotonergic system in the central nervous system. [Prasad S NJIRM 2016; 7(1):59-66]

References

1. Katiyar S K, Agarwal R, Mukhtar H. Inhibition of tumor promotion in SENCAR mouse skin by ethanol extract of Zingiber officinale rhizome. Cancer Research Baltimore 1996; 56, 5: 1023-1030.
2. Guenther Ernest. “The plant family Zingiberaceae” The essential oils, published by D. Van Nostrand Company Canada. Volume-V 1952; 106-20.
3. Evans William Charles. Trease and Evans Pharmacognosy, 13th edition. ELBS 1989; 464-468.
4. Huang Q R, Matsuda H, Sakai K, Yamahara J, Tamai Y. The effect of ginger on serotonin-induced hypothermia and diarrhoea. Yakugaku-Zasshi = Journal of the Pharmaceutical Society of Japan 1990; 110, 12: 936-942.
5. Shigenabu S, Michiko O, Namiko F, Shigenori W. Involvement of dopamine, N-methyl D-aspartate and sigma receptor mechanism in methamphetamine-induced anticipatory activity in rats. J PharmacolExp Therapeutics 1994; 274:688-94.
6. Puri S, Ray A, Chakravarti A K, Sen. P. Role of dopaminergic mechanisms in the regulation of stress responses in experimental animals (Pharm Bioche Behar 1994; 48:53-6.
7. Weilosz M, Kleinrok Z. Lithium induced head twitches in rats. J Pharm Pharmacol 1979; 31: 181-185.
8. TripathiK.D. Essentials of Pharmacology, 4th Edition 1999; 49-51.
9. Naora K, Ding G, Hayashibara M, Katagiri Y, Kano Y, Iwamoto K. Pharmacokinetics of 6-gingerol after intravenous administration in rats with acute renal or hepatic failure. Chemical and Pharmaceutical Bulletin 1992; 40, 5: 1295-1298.
10. Chatterjiee S, Das S N. ‘Analgesic and anti-inflamatory effect of EASE'. Indian J Indg Med 1994; 11: 39-42
11. Singh K. 'Studies on the use of therapeutic ultrasound and a new anti-arthritic drugs (ART) for acute arthritis in Equines', Ph.D. Dissertation submitted to Punjab Agricultural university (PAU), Ludhiyana; 1994.
12. Jana Utpalendu, ChattopadhyayRabindranath, Shaw Badri Prasad. Preliminary studies on anti-inflammatory activity of ZingiberofficinaleRosc.,Vitexnegundo Linn. andTinosporacordifolia (Willid) Miers in Albino rats. Indian Journal of Pharmacology 1999; 31: 323-233.
13. S.S.Prasad,R.R.Pathak, Anupama Desai, Chaitali Shah, S.K.Vajpeyee. V.H. Bhavsar “Investigating the Effects of Ginger-Juice (Zingiber officinale Roscoe) on Amphetamine-induced Locomotor Activity in Rat”. International Journal of Pharmaceutical Sciences and Research, IJPSR 2016; Vol. 7(2): February, 2016
14. S.S.Prasad, R.R.Pathak, Anupama Desai, Chaitali Shah, S.K.Vajpeyee. V.H. Bhavsar “To investigate the effects of GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) on Lithium-induced locomotor activity in rat”. International Journal of Pharmaceutical Sciences and Research, IJPSR 2016; Vol. 7, Issue 2; February, 2016
15. S.S.Prasad, Anupama Desai, Chaitali Shah, S.K.Vajpeyee. V.H. Bhavsar “Effect of Ginger on Isolated Intestine of Rat Establishing it’s Action on Gastro-intestinal Motility and Peristalsis”. International Journal of Current Research in Biosciences and Plant Biology, IJCRBP 2016; Vol. 2(10): 92-97
16. S.S.Prasad,Anupama Desai, Chaitali Shah, Kamlesh Patel, ChandreshDumatar, S.K.Vajpeyee, V.H. Bhavsar “To investigate the effect of GINGER (ZINGIBER OFFICINALE ROSCOE) on pendular intestine motility of rat”. International Journal of
Pharmaceutical Sciences and Research, IJPSR 2015; Vol. 6(9): 4053-4057
17. S.S.Prasad,Anupama Desai, Chaitali Shah, Kamlesh Patel, ChandreshDumatar, S.K.Vajpeyee, V.H. Bhavsar “To investigate the effects of GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) on CNS (locomotor activity) parameters in rat”. International Journal of Pharma Sciences and Research, 2015; 3(6): 606-610
18. S.S.Prasad, Anita Sinha, Kamlesh Patel, ChandreshDumatar, S.K.Vajpeyee, V.H. Bhavsar. “To establish the ulcerogenic potential if any, of GINGER-JUICE ZINGIBER OFFICINALE ROSCOE (ZINGIBERACEAE) on important parameters of gastric ulceration.” International Journal of Pharmaceutical Sciences and Research. IJPSR, 2012; Vol. 3(11): 4472-4476
19. S.S.Prasad, Sushil Kumar, Kamlesh Patel, ChandreshDumater, S.K.Vajpeyee, V.H. Bhavsar. “To investigate the action of GINGER-JUICE ZINGIBER OFFICINALE ROSCOE (ZINGIBERACEAE) on blood coagulation process”. International Journal of Pharma Sciences and Research, 2012; 3(7):407-415
20. S.S.Prasad, Sushil Kumar, S.K.Vajpeyee. V.H. Bhavsar. “To establish the effect of GINGER-JUICE ZINGIBER OFFICINALE ROSCOE (ZINGIBERACEAE) on important parameters of lipid profile.” International Journal of Pharma Sciences and Research, 2012; 3(4): 352-356
21. Dr.S.S.Prasad, Dr.S.K.Vajpeyee, Dr. V.H. Bhavsar. “To Investigate the Antioxidant Property of GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) Using Established AntioxidantParameters”. National Journal of Integrated Research in Medicine, 2012; 3(2):31-3

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Published

2016-02-29

How to Cite

Prasad, S., Shah, C., Desai, A., Vajpeyee, S., & Bhavsar, V. (2016). To Establish The Involvement Of Central Dopaminergic And Serotonergic Mechanism Of Ginger-Juice On Amphetamine And Lithium Treated Rat: To Establish The Involvement Of Ginger-Juice On Amphetamine And Lithium Treated Rat. National Journal of Integrated Research in Medicine, 7(1), 59–66. https://doi.org/10.70284/njirm.v7i1.1046

Issue

Vol. 7 No. 1 (2016)

Section

Original Articles

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