A Comparative Study between outcome of 25% glucose in glycerin and submucosal human placental extract injection in the management of Primary Atrophic Rhinitis

Abstract

Background

Atrophic rhinitis is a chronic disease of the nose. Progressive atrophy of nasal mucosa and underlying turbinates,

formation of scanty viscid secretion and crusts causing foul odor are the cardinal features of this disease. Treatment

can be conservative as well as surgical. This study aimed to compare the outcome of 25% glucose in glycerin

solution and Sub-mucosal human placental extract injection in the management of primary atrophic rhinitis.

Methodology

This study was conducted at Tripura Medical College and Dr. BRAM Teaching Hospital, Tripura, India, from January

2024 to June 2024 with a sample size of 10 after satisfying inclusion and exclusion criteria. Patients who had been

diagnosed with primary atrophic rhinitis were divided into 2 groups, i.e., Group A and Group B. Group A was

administered submucosal human placental extract injection, once a week for 6 months and Group B was advised

25% glucose in glycerin nasal drop, 10 drops in each nostril twice daily for 6 months following which the response

of both the groups was recorded. Collected data was analyzed using Microsoft Excel and SPSS 25.0 software.

Results

Group A (submucosal human placental extract injection) had shown 60% good response while Group B (25%

glucose in glycerin nasal drop) had shown 40% good response after 6 months of treatment. Fair response was

equal in both the groups. Group A had shown 33% poor response while Group B had shown 67% poor response

after 6 months. Out of a total of 10 patients, irrespective of groups, 50% of the patients had shown good response

after 6 months of treatment, combining both the modalities. 20% of patients had shown fair response and the

rest of 30% had shown poor response.

Conclusion

There are various modalities of treatment of primary atrophic rhinitis both surgical and conservative. Treatment

with 25 % glucose in glycerin solution as well as submucosal human placental extract injection both had shown

promising outcomes in various studies. But submucosal placental extract injection had shown better outcome

than 25% glucose in glycerin solution in this study.