A comparative study of N/L ratio in patients of metabolic vs non-metabolic syndrome attending a tertiary care hospital.

Abstract

Background

Numerous studies have shown an association of metabolic syndrome (MS) and insulin resistance with inflammation.

The prevalence of MS as defined by the National Cholesterol Education Programme, Adult Treatment Panel III (NCEP,

ATP), and other criteria indicates ranges from 11% to 41% in India. Neutrophil-lymphocyte ratio, which is calculated

from a routine complete blood count with a widely used marker of inflammation.

Aims and objectives

The aim of the present study was to evaluate the neutrophil-lymphocyte ratio in patients with MS and to correlate

the same with the severity of MS based on the categories of MS.

Materials and Methodology

In this cross-sectional study, 210 patients with and without MS were included after detailed history and examination.

Patients were considered as cases based on the NCEP, ATP III criteria for MS. Both groups of patients were subjected

to routine investigations which included complete blood counts, total white blood counts, neutrophil and lymphocyte

levels, HbA1c levels, serum glucose levels, fasting lipid profile, and electrocardiography. Logistic regression analysis

was done to look for the association of neutrophil-lymphocyte ratio with MS. P < 0.05 was considered as statistically

significant.

Results

It was seen that the neutrophil-lymphocyte ratio in participants without MS was found to be 1.57 ± 0.728 and the ratio

in participants with MS fulfilling 3 out of the 5 criteria, 4 out of 5 and 5 out of 5 criteria were, respectively, 2.65 ± 1.003,

3.59 ± 1.258, and 4.79 ± 2.143. This association was statistically significant with a P = 0.00.

Conclusion

Participants with MS had increased neutrophil-lymphocyte ratio when compared to participants without MS.

Participants fulfilling higher criteria of MS had higher neutrophil-lymphocyte ratio suggesting increasing

inflammatory state.