The association between serum gamma glutamyltransferase levels and microalbuminuria in Type 2 diabetic patients
Keywords:
Microalbuminuria, Diabetic nephropathy, Gamma glutamyltransferase, Oxidative stressAbstract
Background and Objectives Diabetic nephropathy is the major cause of
chronic kidney disease and end stage renal disease in developing
countries. Almost one third of the diabetic patients develop diabetic
nephropathy in their life time. So it is pertinent to detect diabetic
nephropathy at an early (microalbuminuric) stage. The aim of the study
was to evaluate the association of serum GGT with microalbuminuria in
type-2 diabetes mellitus.
Methodology The study comprised of 40 type-2 diabetes mellitus patients
with normoalbuminuria and 40 type-2 diabetes mellitus patients with
microalbuminuria categorised as Group I and Group II respectively.
Results In Pearson’s correlation analysis of serum GGT with urine albumin
levels, the correlation was not statistically significant in Group I subjects
whereas in Group II, a statistically significant correlation was found. A
statistically significant difference was observed between the mean values of fasting blood glucose,
postprandial blood glucose, lipid profile, GGT, HbA1c between Group I and Group II.
Conclusion Interpretation of GGT levels may be a valuable parameter in the evaluation of
microalbuminuria in Type 2 diabetes mellitus.
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