Comparison of NLR,LMR,PLR, RDW, and Platelet count in hematological malignancies at baseline and at intervals of 2 months in patients undergoing chemotherapy

Abstract

Blood cancer has become quite common in all age groups, worldwide. The cancer ranges from acute life

threatening leukemias to indolent chronic leukemias, Lymphoma spillovers causing morbidity and mortality to

slow-growing indolent lymphomas. Since blood is present everywhere in the body hence the spread of

hematological malignancies is massive. Chemotherapy is expensive and a must to treat blood cancers. However,

the ancillary workups like flowcytometry etc in prognosticating and diagnosing blood cancers become quite

cumbersome and heavy on the pocket for an average Indian. Therefore, the authors planned the study aimed at

analyzing-

-Trend in NLR,LMR, PLR RDW, Platelet count at baseline

-Trend in NLR,LMR, PLR RDW, Platelet count 2 months post-chemotherapy

-Comparison between 2 parameters for any significant change

The study was carried out on 11 cases as a prospective case-based study of 11 cases where pre and post-values of

chemotherapy cases of newly diagnosed blood cancer cases were available with the author. The baseline CBC and

post-induction 1 st CBC were used to record the variables under study and latest SPSS software was used to come

to a conclusion through the results.

The findings stated that there was a decline in NLR, PLR and platelet count at follow-up as compared to baseline

and an increase in LMR and RDW at follow-up as compared to baseline, however, the difference was significant

statistically only for PLR (p=0.028) and near significant (p=0.059) for platelet count.

Hence in view of significant findings seen only in 11 cases a larger cohort may be used to correlate these findings

with follow up of such cases.