Molecular medicine techniques in the detection of viral hepatitis

Abstract

Viral hepatitis is a major concern in the public health scenario which has

been the root cause of serious adverse events affecting the human

population. Molecular diagnostics has paved the way for an incredible role in

the advancement of the prognosis and the diagnosis of viral hepatitis.

Significant improvements and modifications in the techniques have led to a

breakthrough in identifying the various reasons underlying the severity of

the various hepatitis viruses causing acute and chronic infections besides

cancer. The molecular biological analysis of the infectious agents involves

detailed investigation of their genomes and their genomic products.

Polymorphism studies have unleashed many important associations of the

diseases with the various genetic variants. Besides these, recombinant DNA

technology, modified sequencing technologies, rational drug designing have

revolutionized the clinical sphere with their varied applications along with an

immense impact on human health. Through the development of novel

genetic methodologies, including a better perception of pathogen biology,

pathogenic mechanisms, recent advances in vaccine development, scheming

new therapeutic drugs and optimization of diagnostic tools, viral hepatitis caused by viral infections are now

better controlled. In this brief review we discuss the developments in the various diagnostic tools in the

detection of the viral infections inflicting the liver in the preceding years along with some recent upcoming

techniques which may revolutionize the treatment and diagnosis of viral hepatitis caused by various viral

infections.