Comparative study of efficacy of methyldopa vs labetalol in the management of pregnancy induced hypertension in respect to maternal and perinatal outcomes

Abstract

This study was a prospective, comparative study, used to determine & compare

the efficacy of treatment with methyldopa vs labetalol with respect to

maternal – perinatal benefits and adverse effects. Conducted in the

Department of Obstetrics and Gynaecology in Vivekananda Institute of

Medical Science, Ramakrishna Mission Seva Pratishthan, a total 425 patients

were taken into the study. The patients were divided into two groups by simple

random sampling method. They were monitored throughout pregnancy and

delivery till 7 days postpartum. The results obtained were divided in 3 sections

Effective BP control, Maternal outcome, Perinatal outcome, which were again

divided into three periods – Antepartum, Intrapartum and Postpartum for

better elaboration. The study revealed that labetalol helps in quicker and more

efficacious control of BP in mothers developing gestational hypertension with

chances of developing preeclampsia – eclampsia syndrome.