Visual outcome in diabetic retinopathy with macular oedema after combined therapy with intravitreal bevacizumab and retinal photocoagulation: An observational case series

Abstract

Purpose

To evaluate the Visual Outcome in Diabetic Retinopathy with Macular Oedema

after Combined Therapy with Intravitreal Avastin (Bevacizumab) and Retinal

Photocoagulation.

Material and Methods

The study included a total of 142 eyes in 142 patients with diabetic macular

oedema. All eyes were treated with intravitreal bevacizumab followed by laser

photocoagulation .Visual outcome was measured in terms of changes in visual

acuity (logMAR) at I month and 3 months after treatment and central macular

thickness using spectral domain Ocular Coherence Tomography (OCT) at 3

months after treatment.

Results

Visual acuity improved from the mean best corrected visual a cuity (BCVA) log

(MAR) of 0.9678 ± 0.2306 at baseline to 0.8928 ± 0.2516 at first visit and then

0.7831 ± 0.2866 at final visit in all 142 patients. OCT determined central

macular thickness changed from a mean value of 624 ± 151 microns at first visit

to 478 ± 141 microns at final visit in all studied subject.

Conclusion

Combined therapy with intravitreal bevacizumab and laser photocoagulation has a role in stabilizing the

retinal anatomy and reducing retinal edema both in NPDR (Non proliferative diabetic retinopathy) and PDR

(Proliferative diabetic retinopathy) with macular oedema. The decrease in the central macular thickness is also

associated with a significant improvement in BCVA.