Clinicopathological study of abnormal uterine bleeding: A two-year study at tertiary care center

Abstract

Background

Histopathological assessment of endometrial samples plays a crucial role in

the diagnosis of abnormal uterine bleeding (AUB). The present study was

conducted to assess histopathology of endometrium with AUB.

Methods

It is a prospective study conducted in the Department of Pathology, Dr

Shankararo Chavan, Government Medical College, Nanded, Maharashtra,

India. All cases attending Gynaecology OPD with AUB were included in

study. The sample received was Dilatation & Curretage (D&C) samples,

endometrial biopsy, polypectomy and hysterectomy specimen. Specimens

were routinely processed and stained with Haematoxylin & Eosin stains and

microscopic morphological evaluation was done and data recorded and

analysed.

Results

We studied 680 cases. Out of which 661 cases showed significant findings and 19 were reported unsatisfactory

samples for evaluation. The commonest histomorphological pattern in these patients were proliferative

endometrium 248(36.47%), leiomyoma 100 (14.70%), adenomyosis 90 (13.23%), endometrial hyperplasia 72

(10.58%), secretory endometrium 47(6.91%), atrophic endometrium 40 (6.91%), endometritis 11 (1.61%),

endometrial polyp 27(3.97%) , adenomyosis with leiomyoma were seen in 23 cases (3.66%) and least number

cases were of endometrial carcinoma forming 3(0.44%) of the total cases taken in the study.

Conclusions

Histopathological examination of endometrium in patient of AUB shows a wide spectrum of changes ranging

from normal endometrium to malignancy. Accurate analysis of endometrial sampling is important in

management of AUB.