A comparative study of effect of tranexamic acid (TXA) parenteral versus local administration in reducing blood loss in total knee replacement

Abstract

Background
Total knee arthroplasty (TKA) is a common orthopaedic surgery that results in significant blood loss due to extensive soft tissue release and bone cuts. The aim of this study is to compare blood loss between parenteral intravenous (IV) administration and local intra-articular (IA) administration of tranexamic acid (TXA), in patients undergoing primary total knee arthroplasty.