Spectral Heart Rate Variability During Late Gestation In Moderately Anaemic Pregnancy

Spectral HRV During Late Gestation In Moderately Anaemic Pregnancy

Authors

  • Dr. Jigna Kher
  • Dr. Hetal Desai

DOI:

https://doi.org/10.70284/njirm.v6i2.873

Keywords:

HRV (Heart rate variability), LF(Low frequency), HF (High frequency)

Abstract

*Tutor cum resident, ** Professor, Department of physiology, SMIMER Medical CollegeSurat, 395 010, India
Abstracts: Backround: Third trimester of pregnancy is associated with profound adaptive autonomic cardiovascular changes. Anaemia in pregnancy, which is a common problem in India, is known to put pregnant female at higher cardiovascular risk. The aim of this study is to measure & compare the cardiovascular autonomic balance in normal pregnancy i.e. control group (Hb ≥ 11.0 g/dl) & pregnancy with moderate anaemia i.e. case group (Hb = 7.0 to 9.9 g/dl). Methodology: Spectral HRV was measured in supine position using digital polyrite and kubios HRV analysis software. Parameters LF(for sympathetic and parasympathetic modulation) , HF(for vagal modulation) in absolute power (ms 2 ) and normalised units (n.u.) and LF/HF ratio for sympathovagal balance were measured and analysed using SPSS 16.0 software. Results: A significantly high LF power(p<0.001) ,low HF power(p<0.001) and high LF/HF ratio (p<0.001) were observed during late gestation period in moderately anaemic pregnant females compared with healthy pregnant females. Conclusion: Third trimester of pregnancy with moderate anaemia has an elevated sympathetic activity and reduced parasympathetic activity characterised by compensatory rise in cardiac output mainly because of rise in stroke volume. Spectral HRV is a better test to diagnose above change than mere measuring heart rate and blood pressure. [Kher J NJIRM 2015; 6(2):10-14]

References

1. Ezzati M, Lopus AD, Dogers A,Vander HS, Murray C.Selected major risk factors and global and regional burden of disease. Lancet 2002;360:1347-60.
2. Demayer EM, Tegman A. Prevalence of anaemia in the world health organ Qlty. 1998; 38:302-16.
3. Dr Vijaynath, Mr.Ramesh S Patil,Mr jitendra,Dr patel Abhisek. Prevalence of Anaemia in pregnancy.Indian journal of Applied Basic Medical Sciences 2010;vol 12B:issue 15.
4. Rang S,Wolf H,Von Montrans G. Non invasive assessment of autonomic cardiovascular control in normal human pregnancy and
pregnancy associated hypertensive disorders. A review, J Hypertension, 2002; 20: 2111- 2119.
5. Lindheimer MD, Wordruff TK. Activin A, Inhibin A and pre eclampsia. Lancet 1997; 349(9061):1266-1267.
6. Stamilio DM, SEhdert HM, Morgan MA, Propert K, Macones GA. Can antenatal clinical and biochemical markers predict the development of severe pre-eclampsia?Am J Obstet Gynecol 2000;182(3):589.
7. Verlohren S, Galindo A, Schlemback d, Zeisler H, Herraiz i, Moertt MG, Pape J, dudenhausen JW, Denk B, Stepan H.An automated method for the determination of the SFIt-1/PIGF ratio in the assessment of pre-eclampsia.AmJobstet gynecol,2010;202:161e.11.
8. Anderson UD, Olsson MG, Kristensln KH, Akerstrom B, Hansson Sr,. Biochemical markers to predict pre-eclampsia: Placenta Review 2012;33:s42-s47 .
9. Papageorghiou AT, YucKH, Erasmus IE, Chuckle Hs . Assessment of risk for the development of pre-eclampsia by maternal characteristics and uterine artery Doppler. BJOG; An intenational J obstet gynecol 2005;112:703-709.
10. Task force of the European society of cardiology,The north American society of Pacing and Electrophysiology. Heart rate variability; Standards of measurement, Physiological interpretation and clinical use. Circulation 1996; 93: 1043 -65.
11. Lauren M Silva, Shalom Dharmanjian, Ph D, TammyY,Euliano MD.Photoplethysmography and heart rate variability for the prediction of pre-eclampsia.
12. Justus DW, Cornett RW, Hatcher JD. A humoral influence on cardiovascular adjustments to acute and chronic post haemorrhagic anaemia in dogs. Circulation 1957; 5(2):207-219.
13. Martin duke, Walter H A elmann.The hemodynamic response to chronic anaemia. Circulation 1969; 39: 503 -515.
14. Lakhotia M, Shah PKD, Gupta A.Clinical assessment of autonomic function in anaemics. J Asso Physician of India 1996; 44(8):534-536.
15. Storstein. On the effect of pure oxygen breathing on the circulation in anoxemia. Acta Med Scand 1952; 143(suppl.269).
16. Glick G, Plauth WH, Jr Brawnwold E.Role of the autonomic nervous system in the circulatory response to acutely induced anaemia in unanaesthetized dogs. J clin. Invest 1964;43(11):2112-2124.
17. C.D.Kuo, G Y chen, M.J.Yang, H.M.Lo and Y.S.Tsai. Biphasic changes in autonomic nervous activity during pregnancy.British J of Anaesthesia 2000;84(0):323-9.
18. Richardson T Q, and Guyton A C. Effects of polycythemia and anaemia on cardiac output and other circulatory factors. Amer J Physiol 1959; 197:1167.
19. Richardson T Q, Guyton A C.Effect of hematocrit on venous return.circulation Research 1961; 9:157.
20. Dekker GA, Sibai BM.Etiology and pathogenesis of pre-eclampsia:current concept. Am J obstet gynecol 1998;179:1359.
21. R Faber, H Stepan, M Baumert, A Voss. Baroreflex sensitivity, Heart rate and Blood pressure variability in hypertensive pregnancy disorders.Journal of Human Hypertension 2004;18:707-712.
22. Yang CC, Chao TL, Kuo TB, Yin CS, Chen HI.Pre eclamptic pregnancy is associated with increased sympathetic and decreased parasympathetic control of HR.AM J Physiol Heart circ Physiol 2000;278:H 1269-73.
23. Abdulnasir Hussen, Deepali Jaju.Investigation of high frequency band of HRV; Identification of pre-eclampsia pregnancy from normal pregnancy in oman. Asian Biomedicine vol.7 no.3 June 2013;339-346.
24. Schobel HP, Fischer T, Heuzer IC, Geiger H, Schmieder RE. Pre eclampsia- a state of sympathetic overactivity.N.Engl.J.Med.1996;335:1480-1485.
25. Greenwood JP, Stoker JB. Walker JJ, Mary DA: Sympathetic nerve discharge in normal pregnancy and pregnancy induced hypertension. J Hypertens 1998;16:617-624.
26. John p Greenwood, Eleanor M Scott, John B Stoker, James J Walker and David A S ,G Mary. Sympathetic neural mechanism in normal and hypertensive pregnancy in human; Circulation 2001;104:2200-2204.

Downloads

Published

2018-01-09

How to Cite

Kher, D. J., & Desai, D. H. (2018). Spectral Heart Rate Variability During Late Gestation In Moderately Anaemic Pregnancy: Spectral HRV During Late Gestation In Moderately Anaemic Pregnancy. National Journal of Integrated Research in Medicine, 6(2), 10–14. https://doi.org/10.70284/njirm.v6i2.873

Issue

Section

Original Articles