Cytological Diagnosis Of Collegenous Spherulosis: A Rare Incidental Finding In Proliferative Breast Lesions

Collegenous Spherulosis of Breast

Abstract

Collagenous spherulosis is a rare incidental finding characterized by collagen rich spherules made up of basement membrane material and is frequently associated with other benign lesions of the breast like fibroadenoma, papilloma, sclerosing adenosis, radial sclerosing lesion, adenomyoepithelioma and florid ductal hyperplasia. The estimated incidence of this innocuous condition is only about 0.2% in cytological material. It is of utmost importance to differentiate collagenous spherulosis from atypical proliferations and malignant mimics especially adenoid cystic carcinoma to avoid unnecessary treatment. Here we discuss the cytological findings of a case of collagenous spherulosis associated with benign proliferative breast disease, along with brief review of literature