Breast Metastasis from Adenocarcinoma of Lung: A Case Report

Abstract

Primary breast cancer is one of the most common malignancies in adult females, in which metastases to the breast represent approximately 0.4% to 1.3% of malignant tumours in the breast. We report a female patient of NSCLC with breast metastatic and discuss clinical, radiological and pathological differential diagnosis. A 30 years old female presented with complaints of cough with haemoptysis and worsening breathing difficulty since 1 month. Lung biopsy shows adenocarcinoma of lung. Patient started chemotherapy with pemetrexated and carboplatin. Clinical examination of the breast shows palpable lump. Patient had undergone breast biopsy to rule out second primary, morphology suggestive of adenocarcinoma. ALK mutation from the breast biopsy come positive, patient started on TKI. Metastasis to the breast, although a rare diagnosis, should be kept on the differential of a patient with primary adenocarcinoma lung cancer. Clinical examination, radiological findings, and immunohistochemistry are very helpful in reaching the proper diagnosis. It has a significant impact on the patient’s treatment modalities and prognosis.