Adult Neuroblastoma of Adrenal gland: Two case report

Abstract

Introduction: Neuroblastoma of the adrenal gland is an extremely rare tumor in adulthood although it is one of the most common malignancies in childhood. The median age of onset is 2 years, with more than 95% of patients younger than 10 years at diagnosis. Considering the location of primary neuroblastoma and the fact that in some instances convincing documentation to support a diagnosis is lacking, these tumors can be diagnosed as other small, round-cell tumors, such as primitive neuroectodermal tumor (PNET)/Ewing’s sarcoma (ES) and olfactory neuroblastoma. Case Reports: Here we present 2 cases of adult neuroblastoma in 23 and 27 years old male patients diagnosed in stage III and IV respectively. Both these patients showed poor outcome. Conclusion: Adults with neuroblastoma have significantly worse outcome than children. This may be due to tumor biology, more virulent clinical course, or possibly due to the fact that adults are less sensitivity or have poor tolerance to pediatric chemotherapy regimens