Congenital Insensitivity to Pain and Anhidrosis: A Series of Three cases from Eastern India

Abstract

Congenital insensitivity to pain and anhidrosis (CIPA) is a very rare genetic disorder caused by mutations in the neurotrophic tyrosine receptor kinase 1 (NTRK1) gene in chromosome 1. The affected children present with congenital lack of pain sensation, inability to sweat, episodes of recurrent hyperpyrexia, mental retardation, and self-mutilating behavior. Here we describe three cases of CIPA from a teaching institute in eastern India.