Isolated orbital metastasis from Adrenal cortical carcinoma – A rare case report with Review of literature

Abstract

Introduction: Adrenal cortical carcinoma (ACC) is a rare tumor which has an aggressive disease course and an early metastasis. When present, metastasis mainly involves lung or bones. Orbital metastasis from adrenal cortical carcinoma is a rare occurrence. The present report describes a case of adrenal cortical carcinoma with isolated orbital metastasis. Case presentation: A 54-year-old postmenopausal women who was operated for adrenal cortical carcinoma 1 year back presented with protrusion of left eye which was diagnosed as isolated metastasis to orbit after complete work up. Conclusion: ACC is a rare and an aggressive tumour with poor long term survival which infrequently spreads to the orbit. The current treatment protocols are disappointing and there is a need for better therapies. Further studies are needed at molecular level to understand the pathogenesis of the disease and to give better outcome.