Carcinosarcoma of Breast: A Rare tumor with Triple Positive Phenotype

Abstract

Primary sarcomas of the breast are rare and constitute 0.6% to 1.2% of the total number of malignant tumors of the breast. Clinically, these are aggressive tumors and majority of them do not express the estrogen and progesterone receptors and do not over express the Her2/neu oncogene. A 35 years female presented with a mass in her right breast. Physical examination and radiological findings were consistent with malignancy. Patient underwent surgery and modified radical mastectomy was performed. Histological examination revealed carcinosarcoma of the breast. On immunohistochemistry, tumor cells were positive for hormone receptors Estrogen Receptor (ER), Progesteron Receptor (PR) and Her2/neu gene, which is a rare entity. The patient is on chemotherapy and hormonal therapy and is under follow up. There was no axillary lymph node involvement or distant metastasis. The present case merits presentation because of its rarity.