Significance of Glycosylated Haemoglobin (Hb) in Diabetic Patients

Significance of Glycosylated Hb in Diabetic Patients

Abstract

In normal, non-diabetic control group subjects, mean glycosylated haemoglobin concentration is 6.68% and range is 5.02 to 7.93.In present study mean glycosylated haemoglobin concentration is 12.90. Glycosylated haemoglobin correlates significantly with the fasting, post prandial levels. Mean of fasting and post –prandial blood sugar level are 178.68 and 226.28 mg /dl respectively. Glycosylated haemoglobin value found higher in female -13.01 compare to make -12.86 Glycosylated haemoglobin values were higher in Juvenile onset diabetes (IDDM) – 14, 20 than Maturity onset diabetes (NIDDM) 12.26. A Glycosylated haemoglobin value has no relation with the long complication of diabetes mellitus. Glycosylated haemoglobin concentration was found high in Insulin taking 15.26 than patients on oral hypoglycaemic agents 12.25 and on dietary restriction 7.81. Single Haemoglobin A1c measurement reflects the mean blood sugar concentration of the patient for the previous two to three months. Therefore, the glycosylated haemoglobin assay provides information about the degree of long term glucose control that is otherwise obtainable in the usual out patients setting. ION EXCHANGE RESIN method can be used routinely to estimate HbA1c in non-diabetic and diabetic patients. Periodic monitoring of HbA 1c should allow the assessment of chronic diabetic control on an out patients basis in a more objective manner than is now possible and enable one to evaluate various forms of therapy and the relationship between carbohydrate control and the progression of various diabetic sequele.