Ocular Sebaceous Gland Carcinoma- A Five Year Experience

Abstract

simulates other entities both clinically and pathologically1. Sebaceous gland carcinoma, also called Meibomian gland carcinoma, is a rare aggressive malignant tumor derived from the adenexal epithelium of sebaceous glands. A five year retrospective review of sebaceous gland carcinoma, eyelid (2008-2013) was conducted in Department of Pathology, Western Regional Institute of Ophthalmology, Ahmedabad.Objective: To study the epidemiological and histological spectrum of Ocular sebaceous gland carcinoma in M&J Western Regional Institute of Ophthalmology, Ahmedabad. Results & Discussion: Among 139 cases of malignant eyelid tumors, 63 cases of sebaceous gland carcinoma (SGC), 47 Squamous cell carcinoma (SCC), 19 Basal cell carcinoma (BCC) and 10 malignant melanoma (MM) were reported. The tumors manifest most frequently on upper eyelid, the mean age at diagnosis was 70 years with 66.7% females. The most common site of origin is the meibomian glands of eyelids, leading to the term meibomian gland carcinoma. Histologically majority of the tumor tended to be moderately differentiated. Results achieved in present study were compared with other previous studies. According to traditional text book knowledge, Sebaceous gland carcinoma is very rare. By contrast our study agrees with other studies from Asia including Indian study; which suggest that it contributes to a recognisable proportion of malignant eyelid tumour. Conclusion: As proved in present study as well as the other studies conducted in past in Asia; Sebaceous gland carcinoma should always be considered in Asian patients, as to a large extent, the surgical approach and management principles differ when those compared to those from other malignant tumours.