Mediators of Resolution in Inflammation: Exploring Avenues
Mediators of Resolution in Inflammation
DOI:
https://doi.org/10.70284/njirm.v6i1.862Keywords:
Inflammation, lipoxins, resolvinsAbstract
Timely resolution of an acute inflammatory response is essential for healthy tissues. Specialized chemical mediators derived from essential fatty acids are identified that actively promote resolution of inflammation via novel pro-resolving and anti-inflammatory cascades. In this review, we summarize potent role of the lipoxins ,resolvins along with other chemical mediators that are enzymatically generated and identified in the resolving inflammatory exudates.[Aruna G NJIRM 2015; 6(1):89-92]
References
1. Serhan CN. Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity?Prostaglandins. 1997 ;53:107-37.
2. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. 2000; J Exp Med 1992: 1197–1204.
3. Serhan CN . Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and proresolution.2002 ;Prostaglandins Other Lipid Mediat 68-69: 433–455.
4. Maderna P, Godson C (2005). Taking insult from injury: lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells.Prostaglandins Leukot Essent Fatty Acids 73: 179–187.
5. Brady HR, Serhan CN. Lipoxins:putative braking signals in host defense, inflammation and hypersensitivity.Curr Opin Nephrol Hypertens.1996;5:20-7.
6. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN (2001). Lipid mediator class switching during acute inflammation: signals in resolution. Nature Immunol 2001; 2: 612–619.
7. Hong S, Gronert K, Devchand P, Moussignac R-L, Serhan CN (2003). Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells:autacoids in anti-inflammation. J Biol Chem 278: 14677–14687.
8. Romano M, Serhan CN. Lipoxin generation by permeabilized human platelets.Biochemistry. 1992; 31: 8269-77.
9. Chiang N, Serhan CN, Dahle NS, DrazenJM, Hay WD et al.The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo 2006 Pharmacol Rev 58:463–487.
10. Brezinski DA, Serhan CN.Characterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: formation of lipoxin A4 by stimulated human whole blood.Biol Mass Spectrom. 1991 Feb;20:45-52.
11. Fiore S, Ryeom SW, Weller PF, and Serhan CN Lipoxin recognition sites: specific binding of labeled lipoxin A4 with human neutrophils. 1992;J Biol Chem 267:16168–16176.
12. Migeotte I, Communi D, Parmentier M . "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses". Cytokine Growth Factor Rev. 2006; 17: 501–19.
13. Jump up^ Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM . "International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family". Pharmacol. Rev. 2009;61 : 119–61.
14. Serhan, C.N., Maddox, J.F., Petasis, N.A., Akritopoulou-Zanze, I., Papayianni, A., Brady, H.R., Colgan, S.P., and Madara, J.L.Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 1995; 34, 14609–14615.
15. O'Sullivan TP, Vallin KS, Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio AL, Perretti M, Godson, C, Guiry PJ. Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities. J. Med.Chem. 2007; 50, 5894–5902.
16. Duffy CD., Maderna P., McCarthy C, Loscher CE, Godson C, Guiry PJ. Synthesis and biologicalevaluation of pyridine-containing lipoxin A(4) analogues. Med. Chem. 2010; 5, 517–522.
17. Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation –resolution programmes, Nature 2007 447: 869-874.
18. Serhan.CN.Resolution phase of inflammation:Novel endogenous antiinflammatory and proresolving Lipid mediators and pathways. Annu Rev Immunol. 2007;25:101-37
19. Serhan CN,Hong S , Gronert K, et al. Resolvins :a family of bioactive products of omega -3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.J Exp med 2002;196:1025-1037.
20. Kantarci. A, Van Dyke. TE. Resolution of inflammation in periodontitis.
J Periodontol. 2005;76: 2168- 2174.
21. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med.2009 16;206:15-23.
2. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. 2000; J Exp Med 1992: 1197–1204.
3. Serhan CN . Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and proresolution.2002 ;Prostaglandins Other Lipid Mediat 68-69: 433–455.
4. Maderna P, Godson C (2005). Taking insult from injury: lipoxins and lipoxin receptor agonists and phagocytosis of apoptotic cells.Prostaglandins Leukot Essent Fatty Acids 73: 179–187.
5. Brady HR, Serhan CN. Lipoxins:putative braking signals in host defense, inflammation and hypersensitivity.Curr Opin Nephrol Hypertens.1996;5:20-7.
6. Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN (2001). Lipid mediator class switching during acute inflammation: signals in resolution. Nature Immunol 2001; 2: 612–619.
7. Hong S, Gronert K, Devchand P, Moussignac R-L, Serhan CN (2003). Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells:autacoids in anti-inflammation. J Biol Chem 278: 14677–14687.
8. Romano M, Serhan CN. Lipoxin generation by permeabilized human platelets.Biochemistry. 1992; 31: 8269-77.
9. Chiang N, Serhan CN, Dahle NS, DrazenJM, Hay WD et al.The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo 2006 Pharmacol Rev 58:463–487.
10. Brezinski DA, Serhan CN.Characterization of lipoxins by combined gas chromatography and electron-capture negative ion chemical ionization mass spectrometry: formation of lipoxin A4 by stimulated human whole blood.Biol Mass Spectrom. 1991 Feb;20:45-52.
11. Fiore S, Ryeom SW, Weller PF, and Serhan CN Lipoxin recognition sites: specific binding of labeled lipoxin A4 with human neutrophils. 1992;J Biol Chem 267:16168–16176.
12. Migeotte I, Communi D, Parmentier M . "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses". Cytokine Growth Factor Rev. 2006; 17: 501–19.
13. Jump up^ Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM . "International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family". Pharmacol. Rev. 2009;61 : 119–61.
14. Serhan, C.N., Maddox, J.F., Petasis, N.A., Akritopoulou-Zanze, I., Papayianni, A., Brady, H.R., Colgan, S.P., and Madara, J.L.Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 1995; 34, 14609–14615.
15. O'Sullivan TP, Vallin KS, Shah ST, Fakhry J, Maderna P, Scannell M, Sampaio AL, Perretti M, Godson, C, Guiry PJ. Aromatic lipoxin A4 and lipoxin B4 analogues display potent biological activities. J. Med.Chem. 2007; 50, 5894–5902.
16. Duffy CD., Maderna P., McCarthy C, Loscher CE, Godson C, Guiry PJ. Synthesis and biologicalevaluation of pyridine-containing lipoxin A(4) analogues. Med. Chem. 2010; 5, 517–522.
17. Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation –resolution programmes, Nature 2007 447: 869-874.
18. Serhan.CN.Resolution phase of inflammation:Novel endogenous antiinflammatory and proresolving Lipid mediators and pathways. Annu Rev Immunol. 2007;25:101-37
19. Serhan CN,Hong S , Gronert K, et al. Resolvins :a family of bioactive products of omega -3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.J Exp med 2002;196:1025-1037.
20. Kantarci. A, Van Dyke. TE. Resolution of inflammation in periodontitis.
J Periodontol. 2005;76: 2168- 2174.
21. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med.2009 16;206:15-23.
Downloads
Published
2018-01-08
How to Cite
G., D. A. (2018). Mediators of Resolution in Inflammation: Exploring Avenues: Mediators of Resolution in Inflammation. National Journal of Integrated Research in Medicine, 6(1), 87–91. https://doi.org/10.70284/njirm.v6i1.862
Issue
Section
Review Article
