Evaluation of Haemoglobin and Iron Levels in Serum of Patients with Oral Sub Mucous Fibrosis: A Clinical Study
Evaluation of Haemoglobin and Iron Levels in Serum
DOI:
https://doi.org/10.70284/njirm.v5i5.797Keywords:
Haemoglobin, Iron Levels, Oral Sub Mucous FibrosisAbstract
Background: Oral sub mucous fibrosis (OSMF) is a chronic, insidious oral mucosal condition affecting the most parts of the oral cavity with high malignant transformation rate triggered by areca nut chewing, nutritional deficiencies, immunologic processes, and genetic predisposition. OSMF causes significant haematological abnormalities resulting in change in levels of various elements. Aim and Objectives: The aim of this study was to estimate the haemoglobin and iron levels in serum among patients with oral sub mucous fibrosis and to compare the values with healthy subjects. Materials and Methods: In this clinical study 50 patients who were diagnosed histopathologically with OSMF and 50 healthy individuals will be included, and the values of haemoglobin levels will be estimated using Sahli's serum iron by Ferrene methods. Results: OSMF patients showed significantly lower levels of haemoglobin and serum iron when compared with the healthy subjects. Conclusion: The present study shows the serum iron assessment for patients with oral sub mucous fibrosis. Determining iron status is a part of biochemical assessment, which may be of proactive intervention for high-risk groups. It is suggested that the biochemical assessment of oral precancerous conditions may help in early diagnosis and prognosis. It is also of key importance that iron therapy should be instituted parallel with the initial diagnosis along with a proper balanced diet, as a part of the overall treatment of oral sub mucous fibrosis with other modes of treatment. This helps to stop the further progression of the condition. [Pathak D NJIRM 2014; 5(5):30-34]
References
2. S. P.Misra, V.Misra,M. Dwivedi, and S. C. Gupta, “Oesophageal subepithelial fibrosis: an extension of oral submucosal fibrosis,†Postgraduate Medical Journal, vol. 74, no. 878, pp. 733– 736, 1998.
3. S. C. Cox and D. M. Walker, “Oral submucous fibrosis. A review,†Australian Dental Journal, vol. 41, no. 5, pp. 294–299,1996.
4. Susan F. Clark. “Iron deficiency anemia: diagnosis and management†Current Opinion in Gastroenterology 2009, 25:122–128.
5. R. Rajendran, T. Vijayakumar, and D. M. Vasudevan, “An alternative pathogenetic pathway for oral submucous fibrosis (OSMF),†Medical Hypotheses, vol. 30, no. 1, pp. 35–37, 1989.
6. R. Rajendran, “Oral submucous fibrosis,†Journal of Oral and Maxillofacial Pathology, vol. 7, pp. 1–4, 2003.
7. S. Khanna, “Immunological and biochemical markers in oral carcinogenesis: the public health perspective,†International Journal of Environmental Research and PublicHealth, vol. 5, no. 5, pp. 418–422, 2008.
8. K. Ranganathan, M. U. Devi, E. Joshua, K. Kirankumar, and T. R. Saraswathi, “Oral submucous fibrosis: a case-control study in Chennai, South India,†Journal of Oral Pathology and Medicine, vol. 33, no. 5, pp. 274–277, 2004.
9. P. V. Angadi and S. S. Rao, “Areca nut in pathogenesis of oral submucous fibrosis: revisited,†Oral and Maxillofacial Surgery, vol. 10, pp. 1–9, 2011.
10. Kiran Kumar K, Saraswathi TR, Ranganathan K, Uma Devi M, Elizabeth J. Oral submucous fibrosis: A clinico-histopathological study in Chennai. Indian J Dent Res 2007;18:106-11.
11. Cox SC, Walker DM. Oral submucous fibrosis: A review. Aust Dent J 1996;41:294-9.
12. S. K. Katharia, S. P. Singh, and V. K. Kulshreshtha, “The effects of placenta extract in management of oral submucous fibrosis,†Indian Journal of Pharmacology, vol. 24, pp. 181–183, 1992.
13. R.Maher, P. Aga, N.W. Johnson, R. Sankaranarayanan, and S. Warnakulasuriya, “Evaluation of multiple micronutrient supplementation in the management of oral submucous fibrosis in Karachi, Pakistan,†Nutrition and Cancer, vol. 27, no. 1, pp. 41–47, 1997.
14. S. Meghji, A. Scutt, J. P. Canniff, W. Harvey, and J. D. Phillipson, “Inhibition of collagenase activity by areca nut tannins: a mechanism of collagen accumulation in oral submucous fibrosis?†Journal of Dental Research, vol. 61, p. 545, 1982.
15. M. Ahmad, S. Ali, A. Ali, and K. Chaubey, “Epidemiological and etiological study of oral submucous fibrosis among gutkha chewers of Patna, Bihar, India,†Journal of Indian Society of Pedodontics and Preventive Dentistry, vol. 24, no. 2, pp. 84–89, 2006.
16. S. F. Clark, “Iron deficiency anemia: diagnosis and management,†Current Opinion in Gastroenterology, vol. 25, no. 2, pp. 122–128, 2009.
17. C. D. Anuradha and C. S. Devi, “Serum protein, ascorbic acid & iron & tissue collagen in oral submucous fibrosis—a preliminary study,†The Indian Journal ofMedical Research, vol. 98, pp. 147–151, 1993.
18. S. S. Khanna and F. R. Karjodkar, “Circulating immune complexes and trace elements (Copper, Iron and Selenium) as markers in oral precancer and cancer : a randomised, controlled clinical trial,†Head & FaceMedicine, vol. 2, p. 33, 2006.
19. P. K. Kakar, R. K. Puri, and V. P. Venkatachalam, “Oral submucous fibrosis—treatment with hyalase,†Journal of Laryngology and Otology, vol. 99, no. 1, pp. 57–59, 1985.
20. C. Trivedy, K. A. A. S. Warnakulasuriya, V. K. Hazarey, M. Tavassoli, P. Sommer, and N. W. Johnson, “The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma,†Journal of Oral Pathology and Medicine, vol. 28, no. 6, pp. 246–251, 1999.
