Estimation Of Salivary Glucose Level And Plasma Glucose Level In Subjects With And Without Diabetes Mellitus: A Comparative Study.
Estimation of salivary glucose level and plasma glucose level in subjects
DOI:
https://doi.org/10.70284/njirm.v5i3.746Keywords:
Diabetes mellitus, Salivary glucose, Serum glucoseAbstract
Objective: The objective of this study was to estimate and correlate salivary glucose levels and plasma glucose levels in non-diabetic subjects, controlled and uncontrolled diabetic subjects and to assess if salivary glucose can be a potentially useful non-invasive tool in diagnosing diabetes mellitus and in monitoring of glycemic control in diabetic patients. Materials and methods: A total of 90 subjects aged between 40-60 years participated in the study. Diabetic status was determined by estimation of random non-fasting plasma glucose levels and Glycosylated haemoglobin levels. Both unstimulated and stimulated saliva were collected and investigated for glucose levels. Salivary glucose levels were measured using the glucose oxidase method. Results: Salivary glucose levels were significantly higher in diabetics than non-diabetics. Mean un-stimulated salivary glucose level was 1.15 mg/dL in control group, 2.04 mg/dL in controlled diabetic group and 3.99 mg/dL in un-controlled diabetic group. There was a significant positive correlation between salivary and plasma glucose levels. Conclusion: These results show that salivary glucose concentration can be used as a potentially useful non-invasive tool for diagnosing diabetes mellitus and monitoring glycemic control in diabetic patients. [Jha S NJIRM 2014; 5(3) :65-70]
References
2. Abikshyeet P. Glucose estimation in the salivary secretion of diabetes mellitus patients diabetic metabolic syndrome and obesity: Targets and Therapy 2012;5:149-54.
3. Shashikumar.R et al. salivary glucose levels and oral candidal carriage in type II diabetics Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:706-711.
4. Saudek.D.C, Herman.W.H, Sacks.D.B, Bergenstal.R.M, Edelman.D, Davidson.M.B. Anew look at screening and diagnosing diabetes mellitus. J Clin Endocrinol Metab, 2008, 93(7):2447-2453.
5. Ayedin.S. A comparision of Ghrelin, Glucose, Alpha amylase and Protein levels in saliva from diabetics. Journal of Biochemistry and Molecular Biology. 2007;40(1):29-35.
6. Jurysta.C et al. Salivary glucose concentration and excretion in normal and diabetic subjects. Journal of Biomedicine and Biotechnology. 2009.
7. Panchbhai.A S et al. Estimation of salivary glucose, salivary amylase, salivary total protein and salivary flow rate in diabetics in India. Journal of Oral Science. 2010;52(3):359-68.
8. Amer. S et al. Salivary glucose concentrations in patients with diabetes mellitus: a minimally invasive technique for monitoring blood glucose levels. Pakistan Journal of Pharmaceutical Sciences. 2001;14(1):33-37.
9. Forbat.LN. Glucose concentrations in parotid fluid and venous blood of patients attending a diabetic clinic. Journal of the Royal Society of Medicine. 1981;74:725-728.
10. Sreedevi et al Comparision of serum glucose and salivary glucose in diabetic patients. Jiaomr 2009; 20(1).
11. Carmen Carda 1, Nezly Mosquera-Lloreda 2, Lucas Salom 3, Maria Elsa Gomez de Ferraris 4, Amando Peydró 5 Structural and functional salivary disorders in type 2 diabetic patients Med Oral Patol Oral Cir Bucal 2006;11:E309-14.
12. Vasconcelos A C U et al. Comparative study of the concentration of salivary and blood glucosein type 2 diabetic patients. Journal of oral science, 2010; 52(2):293-98.
