A Comparative Evaluation Of Lipid Profile In Smokers And Non Smokers
A Comparative Evaluation of Lipid Profile in Smokers
DOI:
https://doi.org/10.70284/njirm.v5i3.745Keywords:
Cardiovascular, Smokers, Hypertension , HypercholesterolemiaAbstract
Background: The major cardiovascular risk factors i.e. smoking, hypertension and hypercholesterolemia; person having only one of these risk factors show a 2-4 times increase in the incidence of coronary heart disease. Studied have also shown the beneficial effect of smoking cessation on the serum lipids, mainly HDL cholesterol. The risk of coronary artery disease reverts rapidly after cessation of smoking. Material and method:-Present study is conducted to reveal the effect of smoking on the lipid profile in male subject. The cross-sectional study was done in 60 male subjects age ranging from 30 to 45 years. The subjects were divided into control group (n=30) and study group i.e. smokers (n=30). All subjects were belongs from either social class 2 or 3 according to Modified Prasad’s social classification. About 5 ml of venous blood will be obtained after 10-12 hours of fasting and analysis of lipid profile was done. Result: Total Cholesterol, Total Triglycerides, High Density Lipoprotein (HDL-Cholesterol), Low Density Lipoprotein (LDL- Cholesterol) and Very Low Density Lipoprotein (VLDL-Cholesterol) will be calculated by Friedwald and Friedrickson formula. There is significant difference in lipid profile parameter of control and smokers. The Total Triglyceride, Total Cholesterol, LDL-Cholesterol ,VLDL-Cholesterol of control and smokers are respectively, which is increase significantly (p<0.05) in smokers then control. The HDL-Cholesterol of control and smokers is decrease significantly (p<0.05) in smokers then control. Conclusion: Hence we concluded that strict measures should be taken up to control the prevalence of the habits of smoking and preventing the risk factor for cardio vascular diseases, hypertension etc. [Gupta N NJIRM 2014; 5(3) :62-64]
References
2. Enas EA, Yusuf S, Mehta JL. Prevalence of coronary artery disease in Asian Indians. Editorial. Am J Cardiol 1992; 70: 945-49.
3. Reddy KS. Cardiovascular diseases in India. World Health Statistics 1993; 46: 101-07.
4. Gupta R, Gupta VP. Meta-analysis of coronary heart disease prevalence in India. Ind Heart J 1996; 48: 241-45.
5. Kannel WB. Importance of hypertension as a major risk factor in cardio vascular disease, in Hypertension: Physiopathology and treatment, GenestJ, Koiw E, KuchelO(Eds) New York, McGraw Hill, 1971; 888-910.
6. Ingo S, Jan E, Peter NE. HDL concentrations increase after stopping smoking. Br Med J 1982; 284: 1511-13.
7. Lipid Research Clinics Program. The Lipid Research Clinics Coronary primary Prevention Trial Results. Reduction in incidence of coronary heart disease. JAMA 1984; 251: 35-64.
8. Prasad BG. Social Classification of Indian families. J Indian Med Assoc 1961;37:250-1.
9. Friedewald WT, Levy RI and Friedrickson DS. Estimation of the concentration of LDL-cholesterol in plasma, without use of the preparative ultracentrifugationâ€. Clin. Chem. 1972; 18:499-502.
10. Neki NS. Lipid Profile in Chronic Smokers. JIACM 2002; 3(1): 51-4.
11. Rastogi R, Shrivastava SSL, Mehotra TN, Singh VS, Gupta MK. Lipid profile in smokers. J- Assoc- Physicians- India 1989; 37(12): 754-756.
12. Goel R et al. A Study of pulmonary function test & lipid profile in asymptomatic smokers.2005;
13. Eisenberg S. High density lipoprotein metabolism. J Lipid Res 1984; 25: 1017.
14. Wilson PWF, Garrison RJ, Abbott RD et al. Factors associated with lipoprotein cholesterol levels. Arteriosclerosis 1983; 3: 274-81.
15. Freeman DJ, Griffen BA, Murray E et al. Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subtraction distribution. Eur J Clin lnv 1993; 23: 630-40.
