Spectrum Of Opportunistic Infections In Human Immunodeficiency Virus Infected Patients
Spectrum Of Opportunistic Infections In HIV
DOI:
https://doi.org/10.70284/njirm.v5i3.728Keywords:
Coccidian parasites HIV infection, opportunistic infections, oropharyngeal candidiasisAbstract
Background & Objectives: Opportunistic infections are common complication seen in HIV infected patients. The type of pathogens responsible for OIs varies from country to country and even from region to region within the same country. Therefore it is important to know the relative frequencies of specific OIs in different parts of the country for appropriate management strategies. This study was designed with an aim to document the pattern of opportunistic infections in HIV infected patients. Methods: The study included 152 HIV positive patients. Depending on the patient’s clinical features, specimens were collected and processed as per standard microbiological protocol for demonstration or isolation of pathogens. Results: In the present study, out of 152 HIV infected patients, 92(60.5%) were males and 60(39.5%) were females. Opportunistic infections were noted in 106 (69.7%) patients. Mycobacterium tuberculosis was the most common bacterial pathogen. Cryptosporidium parvum followed by Isospora belli and Entamoeba histolytica were the major parasites demonstrated in stool of HIV infected patients. Candida spp. was the predominant mycotic pathogen. Conclusion: In HIV infection opportunistic infections account for a considerable proportion of mortality and morbidity. It also necessitates toxic and expensive therapies. The early diagnosis and adequate management of opportunistic infections can slow down the progression to AIDS and need for antiretroviral therapy. [Aher C NJIRM 2014; 5(3) :22-26]
References
2. National AIDS Control Organisation. Guidelines for prevention and management of common opportunistic infections/malignancies among HIV-infected adult and adolescent. May 2007.
3. Ayyagari A, Sharma AK, Prasad KN, Dhole TN, Kishore J, Chaudhary G. Spectrum of opportunistic infections in Human Immunodeficiency Virus (HIV) infected cases in a tertiary care hospital. Indian J Med Microbiol, 2000; 18: 106-109.
4. Deorukhkar SC and Saini S. opportunistic infections in Human Immunodeficiency Virus (HIV) infected patients from rural tertiary care hospital of western Maharashtra. International Journal of Biomedical and Advanced Research. 2012; 03: 908-911.
5. UNAIDS/WHO. UNAIDS/WHO Recommendations. The importance of simple/rapid assays in HIV testing. Weekly Epidemiological Record. 1998; 73: 321-328.
6. Park K. Park’s Textbook of Preventive and Social Medicine. 19th ed. Jabalpur: Banarsidas Bhanot. 2007.
7. World Health Organisation. Basic Laboratory methods in medical parasitology. Geneva: World Health Organisation; 1991: 9-31.
8. World Health Organisation. Basic Laboratory Producers in Clinical bacteriology. 2nd ed. Geneva: World Health Organisation; 2004: 37-59.
9. Raytekar NA, Saini S, Deorukhkar S. Intestinal parasitic prevalence in Human Immuno-deficient Virus (HIV) infected patients with and without diarrhoea and its association with CD4 T cells counts. International Journal of Biomedical and Advance Research. 2012; 03: 853-857.
10. Gupta S, Narang S, Nunavath V, Singh S. Chronic diarrhoea in HIV patients: Prevalence of coccidian parasites. Indian J Med Microbiol. 2008; 26: 172-175.
11. Kumaraswamy N, Solomon S, Flanigan TP, Hemalatha R, Thyagarajan SP, Mayer KH. Natural history of Human Immunodeficiency Virus disease in southern India. Clin Infect Dis. 2003; 36: 79-85.
12. Shailaja VV, Pai LA, Mathur DR, Lakshmi V. Prevalence of bacterial and fungal agents causing lower respiratory tract infection in patients with Human Immunodeficiency Virus infection. Indian J Med Microbiol. 2004; 22: 28-33.
13. Rewari BB (Ed.). Spectrum of opportunistic infections in AIDS. Chapter 11. In: Specialists training and reference module. State Pram (Delhi) National AIDS Control Organisation (New Delhi): 111-120.
14. Deorukhkar S, Katiyar R, Saini S, Siddiqui AU. The prevalence of intestinal parasitic infections in HIV infected patients in a rural tertiary care hospital of western Maharashtra. (A 5 year study). Journal of Clinical and diagnostic Research. 2011; 5: 210-212.
15. Mohandas K, Sehgal R, SudA, Malla N. Prevalence of intestinal parasitic pathogens in HIV- seropositive individuals in Northern India. Jpn J Infect Dis. 2002; 55: 83-84.
16. Hung CC, Yang YL, Lauderdale TL et al. colonization of Human Immunodeficiency Virus-Infected Outpatients in Taiwan with Candida species. J Clin Microbiol. 2005; 43: 1600-1603.
17. Deorukhkar S, Katiyar R, Saini S. Species identification and antifungal pattern of Candida isolates from oropharyngeal lesions of HIV infected patients. National Journal of Integrated Research in Medicine. 2012; 3: 86-90.