Research On Serum Uric Acid In Acute Ischemic Cerebrovascular Stroke

Abstract

Background: The role of uric acid as a risk factor for vascular disease and acute stroke is controversial and there is little information about it. In this study, we determined serum uric acid levels in patients with acute ischemic CV stroke and assessed its relationship with cerebrovascular risk factors. Material And Methods: In this cross sectional study, we have assessed patients with acute ischemic CV stroke who were admitted in SMIMER Hospital from September 2018 to March 2019. Clinical records of patients and their serum uric acid level was investigated. Finally, the collected data was analysed using SPSS software Ver.16. Result: 73 patients with acute stroke were evaluated, 26 of these patients were female and 47of those were male. The mean age of patients was 57.57 ± 1.89 years. Mean serum uric acid levels in the patients studied was 6.72 ± 0.43 mg/dL, and about half of the patients (53%) were hyperuricemic. There was a significant negative correlation between age of patients and their serum uric acid level (p >0.05). Uric acid level was significantly higher in men than women (p <0.05). Hyperuricemia was associated with increased amounts of triglycerides and low-density lipoprotein (LDL) cholesterol (p<0.05). In patients with acute ischemic stroke, there was no significant association between serum uric acid level and diabetes mellitus, hypertension, smoking. Conclusion: Due to the high prevalence of hyperuricemia in patients with acute ischemic stroke, and its accompanying increase in other modifiable risk factors of atherosclerosis, it can be considered as a risk factor for acute ischemic stroke. [Shah A Natl J Integr Res Med, 2020; 11(5):50-55]