Acute Toxicity Study Of An Aqueous Extract Of Dried Leaves Of ‘Gymnosporia Spinosa’ On Albino Mice

Acute Toxicity Study

Abstract

Background: Leaves of G. Spinosa have been used by people for treatment of jaundice. No information is available regarding toxicity studies which prompted us to carry out this work.Method: Acute toxicity study was carried out using aqueous extract of G.Spinosa leaves. for that 28 inbred Swiss albino mice of either sex were randomly divided in to 4 equal group. First group received distilled water (control). Second, third and fourth groups received single dose of drug orally as 40,120 and 240mg/100 g. of Bd. Wt. respectively. Animal were observed for various sign and symptoms. After 72 hrs blood was collected for blood counts and biochemical parameters. Liver, lungs and kidney were subjected to histo-pathological studies. Result: Throughout study there was no mortality in study except degenerative changes in the liver, other organ showed no changes. Analysis of biochemical data showed elevation of S.Alkaline phosphatase and Random blood sugar level.Conclusion: The data showed that hepato-toxicity at higher dose level which is about 100x human therapeutic dose. [Kubavat R Natl J Integr Res Med, 2019; 10(6):23-26]