Histopathological study of salivary gland Lesions

Abstract

Objectives: To study histological pattern for the classification and type of salivary gland lesions and epidmiological pattern.Use of Immunohistochemisrty in histogically mimicking tumors. Methods: Cross sectional study was performed on 79 cases which included biopsies, specimens and referred materials received in pathology department.The samples were examined grossely, processed with hematoxylin and eosin stain for histological confirmation of lesion, special stain and immunohistochemistry done to diagnose some of cases. Results: 79 cases of salivary gland lesions were studied, out of which 28(35.44%) were non neoplastic ,34(43.03%)were benign and 17(21.51%)were malignant SGLs. Benign SGLs were more common in 2^nd -3^rd while malignant tumors were more common in 4^th -6^th decade of life.   Male to female ratio was 1.72:1. Benign tumors were more common in parotid gland 26(81.25%), non-neoplastic lesions 20(54.05%) and malignant tumors 11(29.72%) both were more common in minor salivary glands. Pleomorphic adenoma 27(34.17%) was most common SLG tumor amongst all. Malignant SLG tumors mucoepidermoid carcinoma and adenoid cystic carcinoma had equal incidence 5(6.33%). Immunohistochestry markers were applied in 8(10%) cases. Conclusions: Epidemiological features of most SGLs were similar to previous studies but some differences in age and site related distribution were noted.IHC was found helpful in diagnosis of 8 cases. [Patel R D Natl J Integr Res Med, 2019; 10(5):68-74]