Nosocomial Infections In NICU: Profile And Risk Factors

Nosocomial Infections In NICU: Profile And Risk Factors


  • Alka Bhambri
  • Nisha Pandey


Nosocomial infection, Umbilical sepsis, Eye infection


Background: Nosocomial infections (NIs) in Neonatal Intensive Care Unit (NICU) are one of the leading
causes of mortality and long term morbidity in developing countries. We retrospectively analyzed data of NICU
patients from June 2013- June 2014. Total 120 patients met inclusion criteria. 73 episodes of nosocomial infections
were documented in 67 patients. Eye infection and umbilical sepsis was most common infection followed by systemic
blood infection. Klebsiella Pneumoniae and E. coli were the most common organisms causing sepsis. Chlamydia
trachomatis and Staphylococcus aureus were the most common organisms responsible for eye infection and
umbilical sepsis respectively. Imipenem, Amikacin and Vancomycin showed good sensitivity against most of gram
negative and gram positive organisms respectively. [Pandey N NJIRM 2016; 7(3): 30 - 33]


1. Adams-Chapman I, Stoll BJ. Nosocomial infections
in the nursery. In: Taeusch HW, Ballard RA,
Gleason CA, editors. Avery’s Diseases of the
Newborn. 8th edn. Philadelphia: Elsevier
Saunders; 2005. p. 578–94.
2. Korpela JK, Campbell J, Singh N. Health care
associated infections. In: Mhairi MG, Mullett MD,
Seshia MM, editors. Avery’s Neonatology:
Pathophysiology and Management of the
Newborn. 6th edn. Philadelphia: Lippincott
Williams Wilkins; 2005. p. 1356–83.
3. Garner JS, Jarvis WJ, Emori TG, Horan TC, Hughees
JM. CDC definitions for nosocomial infections. Am J
Infect control 1988; 15 : 128-140.
4. Mohammed Doaa , S. Omnia , Seifi El .Bacterial
nososcomial infections in neonatal intensive care
unit , ZagazigUnivewrsity Hospital , Egypt. Egypt
Pedtric association Gazette 2014;62:72-79.
5. Zafar N, Wallace CM, Kieffer P, Schroeder P,
Schootman M, Hamvas A. Improving survival of
vulnerable infants increases neonatal intensive
care unit nosocomial infection rate. Arch
PediatrAdolesc Med 2001;155:1098–104.
6. Ferguson JK, Gill A. Risk-stratified nosocomial
infection surveillance in a neonatal intensive care
unit: report on 24 months of surveillance. J Pediatr
Child Health 1996;32:525–31.
7. Dal-Bo´ K, Silva RM, Sakae TM. Nosocomial
infections in a neonatal intensive care unit in South
Brazil. Rev Bras TerIntens 2012;24(4):381–5.
8. Abdel-Wahab F, Ghoneim M, Khashaba M, El-
Gilany AH, Abdel-Hady D. Nosocomial infection
surveillance in an Egyptian neonatal intensive care
unit. J Hosp Infect 2013;83(3):196–9.
9. Olsen AL, Reinholdt J, Jensen AM, Andersen LP,
Jensen ET. Nosocomial infection in a Danish
neonatal intensive care unit: a prospective study.
ActaPaediatr 2009;98:1294–8.
10. Holikar S, Bhaisare K, Deshmukh L. Risk factors for
nosocomial sepsis in NICU. Int J Recent Trends
SciTechnol 2012;4(3):141–5.
11. Auriti C, Ronchetti MP, Pezzotti P, Marrocco G,
Quondamcarlo G, Seganti G, et al. Determinants of
nosocomial infection in 6 neonatal intensive care
units an Italian multicenter prospective cohort
study. Infect Control HospEpidemiol
12. Yang LR, Peng MJ, Li H, Pang Y. Pathogen
distribution and risk factors of nosocomial
infections in neonates in the neonatal intensive
care unit. Zhongguo Dang Dai ErKeZaZhi
13. Auriti C, Maccalini A, Di Liso G, et al. Risk factors
fornosocomial infections in a neonatal intensivecare
unit. J HospInfect 2003;53:25–30.
14. Ta´ vora AC, Castro AB, Milita˜o MA, Gira˜o JE,
Ribeiro KB, Ta´ vora LG. Risk factors for nosocomial
infection in a Brazilian neonatal intensive care unit.
Braz J Infect Dis 2008;12(1):75–9.
15. Borguesi A, Stronati M. Strategies for the
prevention of hospital acquired infections in the
neonatal intensive care unit. J Hosp Infect
16. Turkish Neonatal Society; Nosocomial Infections
Study Group.Nosocomial infections in neonatal
units in Turkey: epidemiology,problems, unit
policies and opinions of healthcare workers. Turk
JPediatr 2010;52:50–7.
17. Clark R, Powers R, White R, Bloom B, Sanchez P,
Benjamin JrDK. Nosocomial infection in the NICU: a
medical complicationor unavoidable problem? J
Perinatol 2004;24:382–8.
18. Aziz K, McMillan DD, Andrews W, et al. Variations
in rates ofnosocomial infection among Canadian
neonatal intensive careunits may be practicerelated.
BMC Pediatr 2005;5:22.
19. Mahfouz AA, Al-Azraqi TA, Abbag FI, Al-Gamal MN,
Seef S,Bello CS. Nosocomial infections in a
neonatal intensive care unitin south western Saudi
Arabia. Eastern Med Health J2010;16:40–3.
20. Jeong I, Jeong J, Choi J. Nosocomial infection in a
newbornintensive care unit (NICU), South Korea.
BMC Infect Dis2006;6:103.
21. Kilani RA, Basamad M. Pattern of proven bacterial
sepsis in aneonatal intensive care unit in Riyadh,
Saudi Arabia: a 2-yearanalysis. J Med Liban




How to Cite

Bhambri, A., & Pandey, N. (2018). Nosocomial Infections In NICU: Profile And Risk Factors: Nosocomial Infections In NICU: Profile And Risk Factors. National Journal of Integrated Research in Medicine, 7(3), 30–33. Retrieved from



Original Articles