A case report of Megalencephalic leukoencephalopathy with subcortical cyst in Non-Agarwal Hindu patient

Abstract

Megalencephalic leukoencephalopathy with subcortical cysts(MLC) is a rare genetic disorder, inherited as an
autosomal recessive or autosomal dominantpattern.It predominantly involves white matter of the brain.
Megalencephaly is the most common and earliest clinical finding during infancy, which is followed by progressive
pyramidal signs, ataxia, cognitive impairment and seizures in some patients. Magnetic resonance imaging (MRI)
brain shows predominant frontotemporal white matter involvement with subcortical cysts. Though the majority of
the described cases of MLC in India belongs to the Agarwal community, our patient is non-Agarwal Hindu.