A Comparative Study of Adding Intrathecal Magnesium Sulphate to Bupivacaine Hydrochloride in Spinal Anaesthesia .

Abstract

Introduction : Recently the use of intrathecal adjuvants has gained popularity as they improve the quality of spinal
anesthesia.MgSO4 mainly act as a non-competitive NMDA receptor antagonist by blocking ion channels and
prolong the duration of spinal blockage. The present study is conducted to assess the effectiveness of adding
magnesium sulphate intathecally to bupivacaine in spinal anaesthesia.
Material method : 100 adult patients of both genders, ASA grade I and II were divided randomly in to 2 groups
(n=50). IN GROUP C Inj. Bupivacaine Hydrochloride (15mg) 3ml + 1ml Normal Saline and In GROUP M Inj.
Bupivacaine Hydrochloride (15mg) 3ml + 1ml (50mg) Magnesium sulphate was administered intrathecally.
Hemodynamic changes, Duration of sensory & motor blockade with duration of spinal anasthesia were noted.
Observation & result : Mean Duration of sensory and motor blockade with duration of spinal anesthesia is
statistically highly significant in Group M(p<0.0001) as compared to GROUP C. Adverse drug effects were also
found to be significantly lower in GROUP M as compared to group C. No significant hemodynamic changes were
observed on addition of MgSO4 intrathecally.
Conclusion : Administration of intrathecal MgSO4 to Bupivacaine significantly delays the onset of both sensory
and motor blockade but also prolongs the period of spinal anesthesia without additional side effects.