A Comparative Study of Dosage of MGSO4in Indian Women with Eclampsia.

Abstract

ObjectiveTo assess the safety and efficacy of a low dose magnesium sulfate regimen for the management of
eclampsia in Indian women.Aims & Objectives: 1)To identify the cases of eclampsia who come to dept. Of
obstetrics &gynaecology of C.U.Shah medical college, surendranagar. 2)To treat some cases with Pritchard
regimen & study the efficacy & safety profile. 3)To treat some cases with Low-dose regimen & study the efficacy &
safety profile. 4)To compare the efficacy & safety profile of the two regimens.Methods: A loading dose consisting of
4 gram of magnesium sulfate intravenously plus 6 gram intramuscularly (3 gram in each buttock) was followed by 4
gram intramuscularly every 4 hours, for 24 hours beyond the last seizure. This regimen was evaluated
prospectively with 50 women with eclampsia and the results were compared with Pritchard regimen which was
used in 50 women with eclampsia.Results: Conclusion:The low dose regimen was associated with a lower seizure
recurrence and a slightly lower maternal mortality. This studyconfirm that Low-dose regime is as effective and
safer than Prichard regime.